A protein interaction mechanism for suppressing the mechanosensitive Piezo channels

Mechanosensitive Piezo channels are important for a wide range of mechanotransduction processes. Here the authors show that Piezos interact with sarcoplasmic /endoplasmic-reticulum Ca2+ ATPases (SERCA) and give mechanistic insights into mechanogating and SERCA2-mediated regulation of Piezo1.

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Autores principales:	Tingxin Zhang, Shaopeng Chi, Fan Jiang, Qiancheng Zhao, Bailong Xiao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6beba7b2efeb4c08b83cd2137e93cc51
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spelling	oai:doaj.org-article:6beba7b2efeb4c08b83cd2137e93cc512021-12-02T15:39:05ZA protein interaction mechanism for suppressing the mechanosensitive Piezo channels10.1038/s41467-017-01712-z2041-1723https://doaj.org/article/6beba7b2efeb4c08b83cd2137e93cc512017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01712-zhttps://doaj.org/toc/2041-1723Mechanosensitive Piezo channels are important for a wide range of mechanotransduction processes. Here the authors show that Piezos interact with sarcoplasmic /endoplasmic-reticulum Ca2+ ATPases (SERCA) and give mechanistic insights into mechanogating and SERCA2-mediated regulation of Piezo1.Tingxin ZhangShaopeng ChiFan JiangQiancheng ZhaoBailong XiaoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tingxin Zhang Shaopeng Chi Fan Jiang Qiancheng Zhao Bailong Xiao A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
description	Mechanosensitive Piezo channels are important for a wide range of mechanotransduction processes. Here the authors show that Piezos interact with sarcoplasmic /endoplasmic-reticulum Ca2+ ATPases (SERCA) and give mechanistic insights into mechanogating and SERCA2-mediated regulation of Piezo1.
format	article
author	Tingxin Zhang Shaopeng Chi Fan Jiang Qiancheng Zhao Bailong Xiao
author_facet	Tingxin Zhang Shaopeng Chi Fan Jiang Qiancheng Zhao Bailong Xiao
author_sort	Tingxin Zhang
title	A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
title_short	A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
title_full	A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
title_fullStr	A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
title_full_unstemmed	A protein interaction mechanism for suppressing the mechanosensitive Piezo channels
title_sort	protein interaction mechanism for suppressing the mechanosensitive piezo channels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6beba7b2efeb4c08b83cd2137e93cc51
work_keys_str_mv	AT tingxinzhang aproteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT shaopengchi aproteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT fanjiang aproteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT qianchengzhao aproteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT bailongxiao aproteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT tingxinzhang proteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT shaopengchi proteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT fanjiang proteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT qianchengzhao proteininteractionmechanismforsuppressingthemechanosensitivepiezochannels AT bailongxiao proteininteractionmechanismforsuppressingthemechanosensitivepiezochannels
_version_	1718385993349857280

A protein interaction mechanism for suppressing the mechanosensitive Piezo channels

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