Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis

Objective Primary intestinal lymphomas (PILs) are uncommon tumors, but their incidence is increasing. Currently, their management is centered around systemic treatments, such as chemotherapy and radiotherapy, whereas surgery is restricted to selected indications. This meta-analysis aimed to evaluate...

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Autores principales:	Yefei Shu, Xiaofeng Xu, Wei Yang, Ling Xu
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6bebf4830e0b466f8fa0c5b20c1e8cfc
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spelling	oai:doaj.org-article:6bebf4830e0b466f8fa0c5b20c1e8cfc2021-11-15T00:03:32ZSurgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis1473-230010.1177/03000605211056845https://doaj.org/article/6bebf4830e0b466f8fa0c5b20c1e8cfc2021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211056845https://doaj.org/toc/1473-2300Objective Primary intestinal lymphomas (PILs) are uncommon tumors, but their incidence is increasing. Currently, their management is centered around systemic treatments, such as chemotherapy and radiotherapy, whereas surgery is restricted to selected indications. This meta-analysis aimed to evaluate the role of surgery in PIL treatment. Methods We collected publications comparing surgery plus chemotherapy versus chemotherapy alone in patients with PIL from 2000 to 2021. All trials analyzed the summary odds ratios (ORs) of endpoints, including the 5-year overall survival (OS), 3-year OS, and 3-year progression-free survival rates. Combined pooled ORs were analyzed using fixed- or random-effects models according to heterogeneity. Results Six studies were included. Compared with chemotherapy alone, surgery plus chemotherapy was associated with significantly higher 5-year OS [OR = 4.88, 95%confidence interval (CI) = 1.91–12.44, Z = 3.32], 3-year OS (OR = 3.83, 95%CI = 2.33–6.30, Z = 5.30), and 3-year progression-free survival (OR = 3.51, 95%CI = 2.20–5.58, Z = 5.29). Conclusions Surgery plus chemotherapy was associated with better outcomes than chemotherapy alone, especially in the early stages. Therefore, surgery plus chemotherapy may be the preferred strategy for appropriately selected patients with PIL. The protocol for this systematic review was registered at INPLASY (INPLASY202180102) and is available in full ( https: //doi.org/10.37766/inplasy2021.8.0102 ).Yefei ShuXiaofeng XuWei YangLing XuSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Yefei Shu Xiaofeng Xu Wei Yang Ling Xu Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
description	Objective Primary intestinal lymphomas (PILs) are uncommon tumors, but their incidence is increasing. Currently, their management is centered around systemic treatments, such as chemotherapy and radiotherapy, whereas surgery is restricted to selected indications. This meta-analysis aimed to evaluate the role of surgery in PIL treatment. Methods We collected publications comparing surgery plus chemotherapy versus chemotherapy alone in patients with PIL from 2000 to 2021. All trials analyzed the summary odds ratios (ORs) of endpoints, including the 5-year overall survival (OS), 3-year OS, and 3-year progression-free survival rates. Combined pooled ORs were analyzed using fixed- or random-effects models according to heterogeneity. Results Six studies were included. Compared with chemotherapy alone, surgery plus chemotherapy was associated with significantly higher 5-year OS [OR = 4.88, 95%confidence interval (CI) = 1.91–12.44, Z = 3.32], 3-year OS (OR = 3.83, 95%CI = 2.33–6.30, Z = 5.30), and 3-year progression-free survival (OR = 3.51, 95%CI = 2.20–5.58, Z = 5.29). Conclusions Surgery plus chemotherapy was associated with better outcomes than chemotherapy alone, especially in the early stages. Therefore, surgery plus chemotherapy may be the preferred strategy for appropriately selected patients with PIL. The protocol for this systematic review was registered at INPLASY (INPLASY202180102) and is available in full ( https: //doi.org/10.37766/inplasy2021.8.0102 ).
format	article
author	Yefei Shu Xiaofeng Xu Wei Yang Ling Xu
author_facet	Yefei Shu Xiaofeng Xu Wei Yang Ling Xu
author_sort	Yefei Shu
title	Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
title_short	Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
title_full	Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
title_fullStr	Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
title_full_unstemmed	Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
title_sort	surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/6bebf4830e0b466f8fa0c5b20c1e8cfc
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Surgery plus chemotherapy versus chemotherapy alone in primary intestinal lymphoma: a meta-analysis

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