Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction

Gap junctions are the main form of interaction between cardiomyocytes, through which the electrochemical activities between cardiomyocytes can be synchronized to maintain the normal function of the heart. Connexins are the basis of gap junctions. Changes in the expression, structural changes (e.g.,...

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Autores principales:	Keke Liu, Meng Lv, Xiaodi Ji, Lixia Lou, Bo Nie, Jiuli Zhao, Aiming Wu, Mingjing Zhao
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/6befe00fda8b438e850b15da75f8ad6c
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spelling	oai:doaj.org-article:6befe00fda8b438e850b15da75f8ad6c2021-11-29T00:55:37ZAdvances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction1741-428810.1155/2021/8583285https://doaj.org/article/6befe00fda8b438e850b15da75f8ad6c2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8583285https://doaj.org/toc/1741-4288Gap junctions are the main form of interaction between cardiomyocytes, through which the electrochemical activities between cardiomyocytes can be synchronized to maintain the normal function of the heart. Connexins are the basis of gap junctions. Changes in the expression, structural changes (e.g., phosphorylation and dephosphorylation), and distribution of connexins can affect the normal electrophysiological activities of the heart. Myocardial infarction (MI) and concurrent arrhythmia, shock, or heart failure can endanger life. The structural and functional damage of connexin (Cx) 43 in cardiomyocytes is a central part of the pathological progression of MI and is one of the main pathological mechanisms of arrhythmia after MI. Therefore, increasing Cx43 expression has become one of the main measures to prevent MI. Also, intervention in Cx43 expression can improve the structural and electrical remodeling of the myocardium to improve MI prognosis. Here, research progress of Cx43 in MI and its prevention and treatment using Traditional Chinese Medicine formulations is reviewed.Keke LiuMeng LvXiaodi JiLixia LouBo NieJiuli ZhaoAiming WuMingjing ZhaoHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Other systems of medicine RZ201-999
spellingShingle	Other systems of medicine RZ201-999 Keke Liu Meng Lv Xiaodi Ji Lixia Lou Bo Nie Jiuli Zhao Aiming Wu Mingjing Zhao Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction
description	Gap junctions are the main form of interaction between cardiomyocytes, through which the electrochemical activities between cardiomyocytes can be synchronized to maintain the normal function of the heart. Connexins are the basis of gap junctions. Changes in the expression, structural changes (e.g., phosphorylation and dephosphorylation), and distribution of connexins can affect the normal electrophysiological activities of the heart. Myocardial infarction (MI) and concurrent arrhythmia, shock, or heart failure can endanger life. The structural and functional damage of connexin (Cx) 43 in cardiomyocytes is a central part of the pathological progression of MI and is one of the main pathological mechanisms of arrhythmia after MI. Therefore, increasing Cx43 expression has become one of the main measures to prevent MI. Also, intervention in Cx43 expression can improve the structural and electrical remodeling of the myocardium to improve MI prognosis. Here, research progress of Cx43 in MI and its prevention and treatment using Traditional Chinese Medicine formulations is reviewed.
format	article
author	Keke Liu Meng Lv Xiaodi Ji Lixia Lou Bo Nie Jiuli Zhao Aiming Wu Mingjing Zhao
author_facet	Keke Liu Meng Lv Xiaodi Ji Lixia Lou Bo Nie Jiuli Zhao Aiming Wu Mingjing Zhao
author_sort	Keke Liu
title	Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction
title_short	Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction
title_full	Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction
title_fullStr	Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction
title_full_unstemmed	Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction
title_sort	advances of traditional chinese medicine regulating connexin43 in the prevention and treatment of myocardial infarction
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/6befe00fda8b438e850b15da75f8ad6c
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Advances of Traditional Chinese Medicine Regulating Connexin43 in the Prevention and Treatment of Myocardial Infarction

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