Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Importantly, our study highlights an unusual target on DCs—the α chain of complement receptor 4 (CR4) (CD11c)—for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of an antiviral re...

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Autores principales:	Wilfried Posch, Marta Bermejo-Jambrina, Marion Steger, Christina Witting, Gabriel Diem, Paul Hörtnagl, Hubert Hackl, Cornelia Lass-Flörl, Lukas A. Huber, Teunis B. H. Geijtenbeek, Doris Wilflingseder
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6bf2a44de32345d8b59615a811b9661a
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spelling	oai:doaj.org-article:6bf2a44de32345d8b59615a811b9661a2021-11-03T21:52:35ZComplement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses2150-751110.1128/mBio.02408-21https://doaj.org/article/6bf2a44de32345d8b59615a811b9661a2021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02408-21https://doaj.org/toc/2150-7511 Importantly, our study highlights an unusual target on DCs—the α chain of complement receptor 4 (CR4) (CD11c)—for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of an antiviral recognition pathway in DCs via MAVS.Wilfried PoschMarta Bermejo-JambrinaMarion StegerChristina WittingGabriel DiemPaul HörtnaglHubert HacklCornelia Lass-FlörlLukas A. HuberTeunis B. H. GeijtenbeekDoris WilflingsederAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Wilfried Posch Marta Bermejo-Jambrina Marion Steger Christina Witting Gabriel Diem Paul Hörtnagl Hubert Hackl Cornelia Lass-Flörl Lukas A. Huber Teunis B. H. Geijtenbeek Doris Wilflingseder Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
description	Importantly, our study highlights an unusual target on DCs—the α chain of complement receptor 4 (CR4) (CD11c)—for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of an antiviral recognition pathway in DCs via MAVS.
format	article
author	Wilfried Posch Marta Bermejo-Jambrina Marion Steger Christina Witting Gabriel Diem Paul Hörtnagl Hubert Hackl Cornelia Lass-Flörl Lukas A. Huber Teunis B. H. Geijtenbeek Doris Wilflingseder
author_facet	Wilfried Posch Marta Bermejo-Jambrina Marion Steger Christina Witting Gabriel Diem Paul Hörtnagl Hubert Hackl Cornelia Lass-Flörl Lukas A. Huber Teunis B. H. Geijtenbeek Doris Wilflingseder
author_sort	Wilfried Posch
title	Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
title_short	Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
title_full	Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
title_fullStr	Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
title_full_unstemmed	Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses
title_sort	complement potentiates immune sensing of hiv-1 and early type i interferon responses
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/6bf2a44de32345d8b59615a811b9661a
work_keys_str_mv	AT wilfriedposch complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT martabermejojambrina complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT marionsteger complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT christinawitting complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT gabrieldiem complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT paulhortnagl complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT huberthackl complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT cornelialassflorl complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT lukasahuber complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT teunisbhgeijtenbeek complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses AT doriswilflingseder complementpotentiatesimmunesensingofhiv1andearlytypeiinterferonresponses
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Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

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