Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Importantly, our study highlights an unusual target on DCs—the α chain of complement receptor 4 (CR4) (CD11c)—for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of an antiviral re...

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Autores principales: Wilfried Posch, Marta Bermejo-Jambrina, Marion Steger, Christina Witting, Gabriel Diem, Paul Hörtnagl, Hubert Hackl, Cornelia Lass-Flörl, Lukas A. Huber, Teunis B. H. Geijtenbeek, Doris Wilflingseder
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/6bf2a44de32345d8b59615a811b9661a
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