Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational changes in G and discuss implications for r...

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Autores principales:	Joyce J. W. Wong, Tracy A. Young, Jiayan Zhang, Shiheng Liu, George P. Leser, Elizabeth A. Komives, Robert A. Lamb, Z. Hong Zhou, Joshua Salafsky, Theodore S. Jardetzky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bf2cd0a2e484c86a8eb86d2ea0a7ae4
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spelling	oai:doaj.org-article:6bf2cd0a2e484c86a8eb86d2ea0a7ae42021-12-02T15:38:33ZMonomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation10.1038/s41467-017-00863-32041-1723https://doaj.org/article/6bf2cd0a2e484c86a8eb86d2ea0a7ae42017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00863-3https://doaj.org/toc/2041-1723Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational changes in G and discuss implications for receptor-activated virus entry.Joyce J. W. WongTracy A. YoungJiayan ZhangShiheng LiuGeorge P. LeserElizabeth A. KomivesRobert A. LambZ. Hong ZhouJoshua SalafskyTheodore S. JardetzkyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joyce J. W. Wong Tracy A. Young Jiayan Zhang Shiheng Liu George P. Leser Elizabeth A. Komives Robert A. Lamb Z. Hong Zhou Joshua Salafsky Theodore S. Jardetzky Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation
description	Nipah virus causes encephalitis in humans. Here the authors use a multidisciplinary approach to study the binding of the viral attachment protein G to its host receptor ephrinB2 and show that monomeric and dimeric receptors activate distinct conformational changes in G and discuss implications for receptor-activated virus entry.
format	article
author	Joyce J. W. Wong Tracy A. Young Jiayan Zhang Shiheng Liu George P. Leser Elizabeth A. Komives Robert A. Lamb Z. Hong Zhou Joshua Salafsky Theodore S. Jardetzky
author_facet	Joyce J. W. Wong Tracy A. Young Jiayan Zhang Shiheng Liu George P. Leser Elizabeth A. Komives Robert A. Lamb Z. Hong Zhou Joshua Salafsky Theodore S. Jardetzky
author_sort	Joyce J. W. Wong
title	Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation
title_short	Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation
title_full	Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation
title_fullStr	Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation
title_full_unstemmed	Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation
title_sort	monomeric ephrinb2 binding induces allosteric changes in nipah virus g that precede its full activation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6bf2cd0a2e484c86a8eb86d2ea0a7ae4
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Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

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