Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition

In glioma STAT3 signaling contributes to gliomagenesis. Here, the authors show that Smad6 expression correlates with poor survival and is overexpressed in glioma cells, and regulates STAT3 activity via negatively regulating PIAS3.

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Autores principales: Jiantong Jiao, Rui Zhang, Zheng Li, Ying Yin, Xiangming Fang, Xiaopeng Ding, Ying Cai, Shudong Yang, Huijun Mu, Da Zong, Yuexin Chen, Yansong Zhang, Jian Zou, Junfei Shao, Zhaohui Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6bf4d49429d84fb48d663f6dd8ad532c
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spelling oai:doaj.org-article:6bf4d49429d84fb48d663f6dd8ad532c2021-12-02T16:56:41ZNuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition10.1038/s41467-018-04936-92041-1723https://doaj.org/article/6bf4d49429d84fb48d663f6dd8ad532c2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04936-9https://doaj.org/toc/2041-1723In glioma STAT3 signaling contributes to gliomagenesis. Here, the authors show that Smad6 expression correlates with poor survival and is overexpressed in glioma cells, and regulates STAT3 activity via negatively regulating PIAS3.Jiantong JiaoRui ZhangZheng LiYing YinXiangming FangXiaopeng DingYing CaiShudong YangHuijun MuDa ZongYuexin ChenYansong ZhangJian ZouJunfei ShaoZhaohui HuangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiantong Jiao
Rui Zhang
Zheng Li
Ying Yin
Xiangming Fang
Xiaopeng Ding
Ying Cai
Shudong Yang
Huijun Mu
Da Zong
Yuexin Chen
Yansong Zhang
Jian Zou
Junfei Shao
Zhaohui Huang
Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
description In glioma STAT3 signaling contributes to gliomagenesis. Here, the authors show that Smad6 expression correlates with poor survival and is overexpressed in glioma cells, and regulates STAT3 activity via negatively regulating PIAS3.
format article
author Jiantong Jiao
Rui Zhang
Zheng Li
Ying Yin
Xiangming Fang
Xiaopeng Ding
Ying Cai
Shudong Yang
Huijun Mu
Da Zong
Yuexin Chen
Yansong Zhang
Jian Zou
Junfei Shao
Zhaohui Huang
author_facet Jiantong Jiao
Rui Zhang
Zheng Li
Ying Yin
Xiangming Fang
Xiaopeng Ding
Ying Cai
Shudong Yang
Huijun Mu
Da Zong
Yuexin Chen
Yansong Zhang
Jian Zou
Junfei Shao
Zhaohui Huang
author_sort Jiantong Jiao
title Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
title_short Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
title_full Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
title_fullStr Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
title_full_unstemmed Nuclear Smad6 promotes gliomagenesis by negatively regulating PIAS3-mediated STAT3 inhibition
title_sort nuclear smad6 promotes gliomagenesis by negatively regulating pias3-mediated stat3 inhibition
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/6bf4d49429d84fb48d663f6dd8ad532c
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