Environmental heavy metals and cardiovascular diseases: Status and future direction

Cardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low- and middle-income countries, where concomitant rapid development occu...

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Autores principales:	Ai-Min Yang, Kenneth Lo, Tong-Zhang Zheng, Jing-Li Yang, Ya-Na Bai, Ying-Qing Feng, Ning Cheng, Si-Min Liu
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Heavy metal Cardiovascular disease Hypertension Stroke Coronary heart disease Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6bf588fa8ff7473f88e3c6349cb8b40c
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id	oai:doaj.org-article:6bf588fa8ff7473f88e3c6349cb8b40c
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spelling	oai:doaj.org-article:6bf588fa8ff7473f88e3c6349cb8b40c2021-12-02T14:22:07ZEnvironmental heavy metals and cardiovascular diseases: Status and future direction2095-882X10.1016/j.cdtm.2020.02.005https://doaj.org/article/6bf588fa8ff7473f88e3c6349cb8b40c2020-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300189https://doaj.org/toc/2095-882XCardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low- and middle-income countries, where concomitant rapid development occurs. In this review, we 1) assessed the totality, quantity, and consistency of the available epidemiological studies, linking heavy metal exposures to the risk of CVD (including stroke and coronary heart disease); 2) discussed the potential biological mechanisms underlying some tantalizing observations in humans; and 3) identified gaps in our knowledge base that must be investigated in future work. An accumulating body of evidence from both experimental and observational studies implicates exposure to heavy metals, in a dose-response manner, in the increased risk of CVD. The limitations of most existing studies include insufficient statistical power, lack of comprehensive assessment of exposure, and cross-sectional design. Given the widespread exposure to heavy metals, an urgent need has emerged to investigate these putative associations of environmental exposures, either independently or jointly, with incident CVD outcomes prospectively in well-characterized cohorts of diverse populations, and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations.Ai-Min YangKenneth LoTong-Zhang ZhengJing-Li YangYa-Na BaiYing-Qing FengNing ChengSi-Min LiuKeAi Communications Co., Ltd.articleHeavy metalCardiovascular diseaseHypertensionStrokeCoronary heart diseaseMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 6, Iss 4, Pp 251-259 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Heavy metal Cardiovascular disease Hypertension Stroke Coronary heart disease Medicine (General) R5-920
spellingShingle	Heavy metal Cardiovascular disease Hypertension Stroke Coronary heart disease Medicine (General) R5-920 Ai-Min Yang Kenneth Lo Tong-Zhang Zheng Jing-Li Yang Ya-Na Bai Ying-Qing Feng Ning Cheng Si-Min Liu Environmental heavy metals and cardiovascular diseases: Status and future direction
description	Cardiovascular disease (CVD) and environmental degradation are leading global health problems of our time. Recent studies have linked exposure to heavy metals to the risks of CVD and diabetes, particularly in populations from low- and middle-income countries, where concomitant rapid development occurs. In this review, we 1) assessed the totality, quantity, and consistency of the available epidemiological studies, linking heavy metal exposures to the risk of CVD (including stroke and coronary heart disease); 2) discussed the potential biological mechanisms underlying some tantalizing observations in humans; and 3) identified gaps in our knowledge base that must be investigated in future work. An accumulating body of evidence from both experimental and observational studies implicates exposure to heavy metals, in a dose-response manner, in the increased risk of CVD. The limitations of most existing studies include insufficient statistical power, lack of comprehensive assessment of exposure, and cross-sectional design. Given the widespread exposure to heavy metals, an urgent need has emerged to investigate these putative associations of environmental exposures, either independently or jointly, with incident CVD outcomes prospectively in well-characterized cohorts of diverse populations, and to determine potential strategies to prevent and control the impacts of heavy metal exposure on the cardiometabolic health outcomes of individuals and populations.
format	article
author	Ai-Min Yang Kenneth Lo Tong-Zhang Zheng Jing-Li Yang Ya-Na Bai Ying-Qing Feng Ning Cheng Si-Min Liu
author_facet	Ai-Min Yang Kenneth Lo Tong-Zhang Zheng Jing-Li Yang Ya-Na Bai Ying-Qing Feng Ning Cheng Si-Min Liu
author_sort	Ai-Min Yang
title	Environmental heavy metals and cardiovascular diseases: Status and future direction
title_short	Environmental heavy metals and cardiovascular diseases: Status and future direction
title_full	Environmental heavy metals and cardiovascular diseases: Status and future direction
title_fullStr	Environmental heavy metals and cardiovascular diseases: Status and future direction
title_full_unstemmed	Environmental heavy metals and cardiovascular diseases: Status and future direction
title_sort	environmental heavy metals and cardiovascular diseases: status and future direction
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/6bf588fa8ff7473f88e3c6349cb8b40c
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Environmental heavy metals and cardiovascular diseases: Status and future direction

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