The HSP Immune Network in Cancer

Heat shock proteins are molecular chaperones which support tumor development by regulating various cellular processes including unfolded protein response, mitochondrial bioenergetics, apoptosis, autophagy, necroptosis, lipid metabolism, angiogenesis, cancer cell stemness, epithelial-mesenchymal tran...

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Autores principales:	Zarema Albakova, Yana Mangasarova
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	heat shock proteins tumor immunity immunotherapy cancer extracellular HSPs Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6bf614fa2f8b4019b9e58d916d5d518d
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spelling	oai:doaj.org-article:6bf614fa2f8b4019b9e58d916d5d518d2021-12-01T17:59:39ZThe HSP Immune Network in Cancer1664-322410.3389/fimmu.2021.796493https://doaj.org/article/6bf614fa2f8b4019b9e58d916d5d518d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.796493/fullhttps://doaj.org/toc/1664-3224Heat shock proteins are molecular chaperones which support tumor development by regulating various cellular processes including unfolded protein response, mitochondrial bioenergetics, apoptosis, autophagy, necroptosis, lipid metabolism, angiogenesis, cancer cell stemness, epithelial-mesenchymal transition and tumor immunity. Apart from their intracellular activities, HSPs have also distinct extracellular functions. However, the role that HSP chaperones play in the regulation of immune responses inside and outside the cell is not yet clear. Herein, we explore the intracellular and extracellular immunologic functions of HSPs in cancer. A broader understanding of how HSPs modulate immune responses may provide critical insights for the development of effective immunotherapies.Zarema AlbakovaYana MangasarovaFrontiers Media S.A.articleheat shock proteinstumor immunityimmunotherapycancerextracellular HSPsImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heat shock proteins tumor immunity immunotherapy cancer extracellular HSPs Immunologic diseases. Allergy RC581-607
spellingShingle	heat shock proteins tumor immunity immunotherapy cancer extracellular HSPs Immunologic diseases. Allergy RC581-607 Zarema Albakova Yana Mangasarova The HSP Immune Network in Cancer
description	Heat shock proteins are molecular chaperones which support tumor development by regulating various cellular processes including unfolded protein response, mitochondrial bioenergetics, apoptosis, autophagy, necroptosis, lipid metabolism, angiogenesis, cancer cell stemness, epithelial-mesenchymal transition and tumor immunity. Apart from their intracellular activities, HSPs have also distinct extracellular functions. However, the role that HSP chaperones play in the regulation of immune responses inside and outside the cell is not yet clear. Herein, we explore the intracellular and extracellular immunologic functions of HSPs in cancer. A broader understanding of how HSPs modulate immune responses may provide critical insights for the development of effective immunotherapies.
format	article
author	Zarema Albakova Yana Mangasarova
author_facet	Zarema Albakova Yana Mangasarova
author_sort	Zarema Albakova
title	The HSP Immune Network in Cancer
title_short	The HSP Immune Network in Cancer
title_full	The HSP Immune Network in Cancer
title_fullStr	The HSP Immune Network in Cancer
title_full_unstemmed	The HSP Immune Network in Cancer
title_sort	hsp immune network in cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/6bf614fa2f8b4019b9e58d916d5d518d
work_keys_str_mv	AT zaremaalbakova thehspimmunenetworkincancer AT yanamangasarova thehspimmunenetworkincancer AT zaremaalbakova hspimmunenetworkincancer AT yanamangasarova hspimmunenetworkincancer
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The HSP Immune Network in Cancer

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