Zika virus challenges for neuropsychiatry

Ana Cristina Simões e Silva,1,2 Janaina Matos Moreira,1,2 Roberta Maia Castro Romanelli,2 Antonio Lucio Teixeira1,3 1Interdisciplinary Laboratory of Medical Investigation, 2Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, ...

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Autores principales:	Simões e Silva AC, Moreira JM, Romanelli RMC, Teixeira AL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Zika virus Microcephaly Guillain–Barré syndrome Neurodevelopmental disorders. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/6bf93967ef954e81b6f43dd1fbc8a5ed
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spelling	oai:doaj.org-article:6bf93967ef954e81b6f43dd1fbc8a5ed2021-12-02T08:59:21ZZika virus challenges for neuropsychiatry1178-2021https://doaj.org/article/6bf93967ef954e81b6f43dd1fbc8a5ed2016-07-01T00:00:00Zhttps://www.dovepress.com/zika-virus-challenges-for-neuropsychiatry-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ana Cristina Simões e Silva,1,2 Janaina Matos Moreira,1,2 Roberta Maia Castro Romanelli,2 Antonio Lucio Teixeira1,3 1Interdisciplinary Laboratory of Medical Investigation, 2Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; 3Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA Abstract: Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain–Barré syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations. Keywords: Zika virus, microcephaly, Guillain–Barré syndrome, neurodevelopmental disordersSimões e Silva ACMoreira JMRomanelli RMCTeixeira ALDove Medical PressarticleZika virusMicrocephalyGuillain–Barré syndromeNeurodevelopmental disorders.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1747-1760 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zika virus Microcephaly Guillain–Barré syndrome Neurodevelopmental disorders. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Zika virus Microcephaly Guillain–Barré syndrome Neurodevelopmental disorders. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Simões e Silva AC Moreira JM Romanelli RMC Teixeira AL Zika virus challenges for neuropsychiatry
description	Ana Cristina Simões e Silva,1,2 Janaina Matos Moreira,1,2 Roberta Maia Castro Romanelli,2 Antonio Lucio Teixeira1,3 1Interdisciplinary Laboratory of Medical Investigation, 2Department of Pediatrics, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil; 3Neuropsychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA Abstract: Before 2007, Zika virus (ZIKV) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical Africa and Southeast Asia. Currently, a large, ongoing outbreak of ZIKV that started in Brazil in 2015 is spreading across the Americas. Virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. In addition to congenital malformations, a temporal association between ZIKV infection and an increase in cases of Guillain–Barré syndrome is currently being observed in several countries. The mechanisms underlying these neurological complications are still unknown. Emerging evidence, mainly from in vitro studies, suggests that ZIKV may have direct effects on neuronal cells. The aim of this study was to critically review the literature available regarding the neurobiology of ZIKV and its potential neuropsychiatric manifestations. Keywords: Zika virus, microcephaly, Guillain–Barré syndrome, neurodevelopmental disorders
format	article
author	Simões e Silva AC Moreira JM Romanelli RMC Teixeira AL
author_facet	Simões e Silva AC Moreira JM Romanelli RMC Teixeira AL
author_sort	Simões e Silva AC
title	Zika virus challenges for neuropsychiatry
title_short	Zika virus challenges for neuropsychiatry
title_full	Zika virus challenges for neuropsychiatry
title_fullStr	Zika virus challenges for neuropsychiatry
title_full_unstemmed	Zika virus challenges for neuropsychiatry
title_sort	zika virus challenges for neuropsychiatry
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6bf93967ef954e81b6f43dd1fbc8a5ed
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Zika virus challenges for neuropsychiatry

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