Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways

DNA methylation plays an important role in regulating a wide variety of cellular processes and is implicated in a range of diseases. Here the authors present Casilio-ME to assemble protein complexes to demethylate target loci.

Guardado en:

Detalles Bibliográficos
Autores principales:	Aziz Taghbalout, Menghan Du, Nathaniel Jillette, Wojciech Rosikiewicz, Abhijit Rath, Christopher D. Heinen, Sheng Li, Albert W. Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bfa03502fb24550a614110069d7480f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6bfa03502fb24550a614110069d7480f
record_format	dspace
spelling	oai:doaj.org-article:6bfa03502fb24550a614110069d7480f2021-12-02T16:57:19ZEnhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways10.1038/s41467-019-12339-72041-1723https://doaj.org/article/6bfa03502fb24550a614110069d7480f2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12339-7https://doaj.org/toc/2041-1723DNA methylation plays an important role in regulating a wide variety of cellular processes and is implicated in a range of diseases. Here the authors present Casilio-ME to assemble protein complexes to demethylate target loci.Aziz TaghbaloutMenghan DuNathaniel JilletteWojciech RosikiewiczAbhijit RathChristopher D. HeinenSheng LiAlbert W. ChengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aziz Taghbalout Menghan Du Nathaniel Jillette Wojciech Rosikiewicz Abhijit Rath Christopher D. Heinen Sheng Li Albert W. Cheng Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
description	DNA methylation plays an important role in regulating a wide variety of cellular processes and is implicated in a range of diseases. Here the authors present Casilio-ME to assemble protein complexes to demethylate target loci.
format	article
author	Aziz Taghbalout Menghan Du Nathaniel Jillette Wojciech Rosikiewicz Abhijit Rath Christopher D. Heinen Sheng Li Albert W. Cheng
author_facet	Aziz Taghbalout Menghan Du Nathaniel Jillette Wojciech Rosikiewicz Abhijit Rath Christopher D. Heinen Sheng Li Albert W. Cheng
author_sort	Aziz Taghbalout
title	Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
title_short	Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
title_full	Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
title_fullStr	Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
title_full_unstemmed	Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways
title_sort	enhanced crispr-based dna demethylation by casilio-me-mediated rna-guided coupling of methylcytosine oxidation and dna repair pathways
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6bfa03502fb24550a614110069d7480f
work_keys_str_mv	AT aziztaghbalout enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT menghandu enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT nathanieljillette enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT wojciechrosikiewicz enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT abhijitrath enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT christopherdheinen enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT shengli enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways AT albertwcheng enhancedcrisprbaseddnademethylationbycasiliomemediatedrnaguidedcouplingofmethylcytosineoxidationanddnarepairpathways
_version_	1718382570052255744

Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways

Ejemplares similares