Membrane cholesterol access into a G-protein-coupled receptor

G-protein-coupled receptors trigger several signalling pathways and their activity was proposed to be allosteric modulated by cholesterol. Here the authors use molecular dynamics simulations and ligand binding assays to show that membrane cholesterol can bind to adenosine A2Areceptor orthosteric sit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ramon Guixà-González, José L. Albasanz, Ismael Rodriguez-Espigares, Manuel Pastor, Ferran Sanz, Maria Martí-Solano, Moutusi Manna, Hector Martinez-Seara, Peter W. Hildebrand, Mairena Martín, Jana Selent
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6bfe51cbb81e47ca99f372882e589358
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6bfe51cbb81e47ca99f372882e589358
record_format	dspace
spelling	oai:doaj.org-article:6bfe51cbb81e47ca99f372882e5893582021-12-02T15:37:06ZMembrane cholesterol access into a G-protein-coupled receptor10.1038/ncomms145052041-1723https://doaj.org/article/6bfe51cbb81e47ca99f372882e5893582017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14505https://doaj.org/toc/2041-1723G-protein-coupled receptors trigger several signalling pathways and their activity was proposed to be allosteric modulated by cholesterol. Here the authors use molecular dynamics simulations and ligand binding assays to show that membrane cholesterol can bind to adenosine A2Areceptor orthosteric site.Ramon Guixà-GonzálezJosé L. AlbasanzIsmael Rodriguez-EspigaresManuel PastorFerran SanzMaria Martí-SolanoMoutusi MannaHector Martinez-SearaPeter W. HildebrandMairena MartínJana SelentNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ramon Guixà-González José L. Albasanz Ismael Rodriguez-Espigares Manuel Pastor Ferran Sanz Maria Martí-Solano Moutusi Manna Hector Martinez-Seara Peter W. Hildebrand Mairena Martín Jana Selent Membrane cholesterol access into a G-protein-coupled receptor
description	G-protein-coupled receptors trigger several signalling pathways and their activity was proposed to be allosteric modulated by cholesterol. Here the authors use molecular dynamics simulations and ligand binding assays to show that membrane cholesterol can bind to adenosine A2Areceptor orthosteric site.
format	article
author	Ramon Guixà-González José L. Albasanz Ismael Rodriguez-Espigares Manuel Pastor Ferran Sanz Maria Martí-Solano Moutusi Manna Hector Martinez-Seara Peter W. Hildebrand Mairena Martín Jana Selent
author_facet	Ramon Guixà-González José L. Albasanz Ismael Rodriguez-Espigares Manuel Pastor Ferran Sanz Maria Martí-Solano Moutusi Manna Hector Martinez-Seara Peter W. Hildebrand Mairena Martín Jana Selent
author_sort	Ramon Guixà-González
title	Membrane cholesterol access into a G-protein-coupled receptor
title_short	Membrane cholesterol access into a G-protein-coupled receptor
title_full	Membrane cholesterol access into a G-protein-coupled receptor
title_fullStr	Membrane cholesterol access into a G-protein-coupled receptor
title_full_unstemmed	Membrane cholesterol access into a G-protein-coupled receptor
title_sort	membrane cholesterol access into a g-protein-coupled receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6bfe51cbb81e47ca99f372882e589358
work_keys_str_mv	AT ramonguixagonzalez membranecholesterolaccessintoagproteincoupledreceptor AT joselalbasanz membranecholesterolaccessintoagproteincoupledreceptor AT ismaelrodriguezespigares membranecholesterolaccessintoagproteincoupledreceptor AT manuelpastor membranecholesterolaccessintoagproteincoupledreceptor AT ferransanz membranecholesterolaccessintoagproteincoupledreceptor AT mariamartisolano membranecholesterolaccessintoagproteincoupledreceptor AT moutusimanna membranecholesterolaccessintoagproteincoupledreceptor AT hectormartinezseara membranecholesterolaccessintoagproteincoupledreceptor AT peterwhildebrand membranecholesterolaccessintoagproteincoupledreceptor AT mairenamartin membranecholesterolaccessintoagproteincoupledreceptor AT janaselent membranecholesterolaccessintoagproteincoupledreceptor
_version_	1718386238290919424

Membrane cholesterol access into a G-protein-coupled receptor

Ejemplares similares