Molecular preservation in mammoth bone and variation based on burial environment

Abstract Biomolecules preserved in fossils are expanding our understanding of the biology and evolution of ancient animals. Molecular taphonomy seeks to understand how these biomolecules are preserved and how they can be interpreted. So far, few studies on molecular preservation have considered buri...

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Autores principales:	Caitlin Colleary, Hector M. Lamadrid, Shane S. O’Reilly, Andrei Dolocan, Sterling J. Nesbitt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6bff673d0ed84453ac6fb19240a94a77
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spelling	oai:doaj.org-article:6bff673d0ed84453ac6fb19240a94a772021-12-02T13:27:32ZMolecular preservation in mammoth bone and variation based on burial environment10.1038/s41598-021-81849-62045-2322https://doaj.org/article/6bff673d0ed84453ac6fb19240a94a772021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81849-6https://doaj.org/toc/2045-2322Abstract Biomolecules preserved in fossils are expanding our understanding of the biology and evolution of ancient animals. Molecular taphonomy seeks to understand how these biomolecules are preserved and how they can be interpreted. So far, few studies on molecular preservation have considered burial context to understand its impact on preservation or the potentially complementary information from multiple biomolecular classes. Here, we use mass spectrometry and other analytical techniques to detect the remains of proteins and lipids within intact fossil mammoth bones of different ages and varied depositional setting. By combining these approaches, we demonstrate that endogenous amino acids, amides and lipids can preserve well in fossil bone. Additionally, these techniques enable us to examine variation in preservation based on location within the bone, finding dense cortical bone better preserves biomolecules, both by slowing the rate of degradation and limiting the extent of exogenous contamination. Our dataset demonstrates that biomolecule loss begins early, is impacted by burial environment and temperature, and that both exogenous and endogenous molecular signals can be both present and informative in a single fossil.Caitlin CollearyHector M. LamadridShane S. O’ReillyAndrei DolocanSterling J. NesbittNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caitlin Colleary Hector M. Lamadrid Shane S. O’Reilly Andrei Dolocan Sterling J. Nesbitt Molecular preservation in mammoth bone and variation based on burial environment
description	Abstract Biomolecules preserved in fossils are expanding our understanding of the biology and evolution of ancient animals. Molecular taphonomy seeks to understand how these biomolecules are preserved and how they can be interpreted. So far, few studies on molecular preservation have considered burial context to understand its impact on preservation or the potentially complementary information from multiple biomolecular classes. Here, we use mass spectrometry and other analytical techniques to detect the remains of proteins and lipids within intact fossil mammoth bones of different ages and varied depositional setting. By combining these approaches, we demonstrate that endogenous amino acids, amides and lipids can preserve well in fossil bone. Additionally, these techniques enable us to examine variation in preservation based on location within the bone, finding dense cortical bone better preserves biomolecules, both by slowing the rate of degradation and limiting the extent of exogenous contamination. Our dataset demonstrates that biomolecule loss begins early, is impacted by burial environment and temperature, and that both exogenous and endogenous molecular signals can be both present and informative in a single fossil.
format	article
author	Caitlin Colleary Hector M. Lamadrid Shane S. O’Reilly Andrei Dolocan Sterling J. Nesbitt
author_facet	Caitlin Colleary Hector M. Lamadrid Shane S. O’Reilly Andrei Dolocan Sterling J. Nesbitt
author_sort	Caitlin Colleary
title	Molecular preservation in mammoth bone and variation based on burial environment
title_short	Molecular preservation in mammoth bone and variation based on burial environment
title_full	Molecular preservation in mammoth bone and variation based on burial environment
title_fullStr	Molecular preservation in mammoth bone and variation based on burial environment
title_full_unstemmed	Molecular preservation in mammoth bone and variation based on burial environment
title_sort	molecular preservation in mammoth bone and variation based on burial environment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6bff673d0ed84453ac6fb19240a94a77
work_keys_str_mv	AT caitlincolleary molecularpreservationinmammothboneandvariationbasedonburialenvironment AT hectormlamadrid molecularpreservationinmammothboneandvariationbasedonburialenvironment AT shanesoreilly molecularpreservationinmammothboneandvariationbasedonburialenvironment AT andreidolocan molecularpreservationinmammothboneandvariationbasedonburialenvironment AT sterlingjnesbitt molecularpreservationinmammothboneandvariationbasedonburialenvironment
_version_	1718392979580780544

Molecular preservation in mammoth bone and variation based on burial environment

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