Molecular and cellular mechanisms of adipogenesis

The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue. The volume of adipose tissue depends on the size of individual adipoc...

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Autores principales:	Alexander Dmitrievich Egorov, Dmitry Nikolaevich Penkov, Vsevolod Arsen'evich Tkachuk
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	adipogenesis transcription factors transcriptional activation ppar? homeodomain proteins Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/6c05b5cc8026490b897b25b3aea741fa
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spelling	oai:doaj.org-article:6c05b5cc8026490b897b25b3aea741fa2021-11-14T09:00:19ZMolecular and cellular mechanisms of adipogenesis2072-03512072-037810.14341/DM2015212-19https://doaj.org/article/6c05b5cc8026490b897b25b3aea741fa2015-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6824https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue. The volume of adipose tissue depends on the size of individual adipocytes and on their number. The number of adipocytes increases as a result of enhanced adipocyte differentiation. The transcriptional cascade that regulates this differentiation has been well studied. The major adipogenic transcription factor peroxisome proliferator-activated receptor gamma is a ligand-activated nuclear receptor with essential roles in adipogenesis. Its ligands are used to treat metabolic syndrome and type 2 diabetes mellitus. . The present article describes the basic molecular and cellular mechanisms of adipogenesis and discusses the impact of insulin, glucocorticoids, cyclic adenosine monophosphate-activating agents, nuclear receptors and transcription factors on the process of adipogenesis. New regulatory regions of the genome that are capable of binding multiple transcription factors are described, and the most promising drug targets for the treatment of metabolic syndrome and obesity, including the homeodomain proteins Pbx1 and Prep1, are discussed..Alexander Dmitrievich EgorovDmitry Nikolaevich PenkovVsevolod Arsen'evich TkachukEndocrinology Research Centrearticleadipogenesistranscription factorstranscriptional activationppar?homeodomain proteinsNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 2, Pp 12-19 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	adipogenesis transcription factors transcriptional activation ppar? homeodomain proteins Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	adipogenesis transcription factors transcriptional activation ppar? homeodomain proteins Nutritional diseases. Deficiency diseases RC620-627 Alexander Dmitrievich Egorov Dmitry Nikolaevich Penkov Vsevolod Arsen'evich Tkachuk Molecular and cellular mechanisms of adipogenesis
description	The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue. The volume of adipose tissue depends on the size of individual adipocytes and on their number. The number of adipocytes increases as a result of enhanced adipocyte differentiation. The transcriptional cascade that regulates this differentiation has been well studied. The major adipogenic transcription factor peroxisome proliferator-activated receptor gamma is a ligand-activated nuclear receptor with essential roles in adipogenesis. Its ligands are used to treat metabolic syndrome and type 2 diabetes mellitus. . The present article describes the basic molecular and cellular mechanisms of adipogenesis and discusses the impact of insulin, glucocorticoids, cyclic adenosine monophosphate-activating agents, nuclear receptors and transcription factors on the process of adipogenesis. New regulatory regions of the genome that are capable of binding multiple transcription factors are described, and the most promising drug targets for the treatment of metabolic syndrome and obesity, including the homeodomain proteins Pbx1 and Prep1, are discussed..
format	article
author	Alexander Dmitrievich Egorov Dmitry Nikolaevich Penkov Vsevolod Arsen'evich Tkachuk
author_facet	Alexander Dmitrievich Egorov Dmitry Nikolaevich Penkov Vsevolod Arsen'evich Tkachuk
author_sort	Alexander Dmitrievich Egorov
title	Molecular and cellular mechanisms of adipogenesis
title_short	Molecular and cellular mechanisms of adipogenesis
title_full	Molecular and cellular mechanisms of adipogenesis
title_fullStr	Molecular and cellular mechanisms of adipogenesis
title_full_unstemmed	Molecular and cellular mechanisms of adipogenesis
title_sort	molecular and cellular mechanisms of adipogenesis
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/6c05b5cc8026490b897b25b3aea741fa
work_keys_str_mv	AT alexanderdmitrievichegorov molecularandcellularmechanismsofadipogenesis AT dmitrynikolaevichpenkov molecularandcellularmechanismsofadipogenesis AT vsevolodarsenevichtkachuk molecularandcellularmechanismsofadipogenesis
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Molecular and cellular mechanisms of adipogenesis

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