Impact of proton therapy on antitumor immune response

Abstract Radiotherapy delivered using photons induces an immune response that leads to modulation of the tumor microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors in association with photon radiotherapy. At present, there is no publication on the radio-induced imm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Céline Mirjolet, Anaïs Nicol, Emeric Limagne, Carole Mura, Corentin Richard, Véronique Morgand, Marc Rousseau, Romain Boidot, François Ghiringhelli, Georges Noel, Hélène Burckel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c06ec6e3d0548fbbddd6f3023616eb5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c06ec6e3d0548fbbddd6f3023616eb5
record_format	dspace
spelling	oai:doaj.org-article:6c06ec6e3d0548fbbddd6f3023616eb52021-12-02T16:10:37ZImpact of proton therapy on antitumor immune response10.1038/s41598-021-92942-12045-2322https://doaj.org/article/6c06ec6e3d0548fbbddd6f3023616eb52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92942-1https://doaj.org/toc/2045-2322Abstract Radiotherapy delivered using photons induces an immune response that leads to modulation of the tumor microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors in association with photon radiotherapy. At present, there is no publication on the radio-induced immune response after proton therapy. Balb/c mice bearing subcutaneous CT26 colon tumors were irradiated by a single fraction of 16.4 Gy using a proton beam extracted from a TR24 cyclotron. RNA sequencing analysis was assessed at 3 days post-treatment. Proton therapy immune response was monitored by flow cytometry using several panels (lymphoid, myeloid cells, lymphoid cytokines) at 7 and 14 days post-irradiation. RNA-Seq functional profiling identified a large number of GO categories linked to “immune response” and “interferon signaling”. Immunomonitoring evaluation showed induced tumor infiltration by immune cells. This is the first study showing the effect of proton therapy on immune response. These interesting results provide a sound basis to assess the efficacy of a combination of proton therapy and immune checkpoint inhibitors.Céline MirjoletAnaïs NicolEmeric LimagneCarole MuraCorentin RichardVéronique MorgandMarc RousseauRomain BoidotFrançois GhiringhelliGeorges NoelHélène BurckelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Céline Mirjolet Anaïs Nicol Emeric Limagne Carole Mura Corentin Richard Véronique Morgand Marc Rousseau Romain Boidot François Ghiringhelli Georges Noel Hélène Burckel Impact of proton therapy on antitumor immune response
description	Abstract Radiotherapy delivered using photons induces an immune response that leads to modulation of the tumor microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors in association with photon radiotherapy. At present, there is no publication on the radio-induced immune response after proton therapy. Balb/c mice bearing subcutaneous CT26 colon tumors were irradiated by a single fraction of 16.4 Gy using a proton beam extracted from a TR24 cyclotron. RNA sequencing analysis was assessed at 3 days post-treatment. Proton therapy immune response was monitored by flow cytometry using several panels (lymphoid, myeloid cells, lymphoid cytokines) at 7 and 14 days post-irradiation. RNA-Seq functional profiling identified a large number of GO categories linked to “immune response” and “interferon signaling”. Immunomonitoring evaluation showed induced tumor infiltration by immune cells. This is the first study showing the effect of proton therapy on immune response. These interesting results provide a sound basis to assess the efficacy of a combination of proton therapy and immune checkpoint inhibitors.
format	article
author	Céline Mirjolet Anaïs Nicol Emeric Limagne Carole Mura Corentin Richard Véronique Morgand Marc Rousseau Romain Boidot François Ghiringhelli Georges Noel Hélène Burckel
author_facet	Céline Mirjolet Anaïs Nicol Emeric Limagne Carole Mura Corentin Richard Véronique Morgand Marc Rousseau Romain Boidot François Ghiringhelli Georges Noel Hélène Burckel
author_sort	Céline Mirjolet
title	Impact of proton therapy on antitumor immune response
title_short	Impact of proton therapy on antitumor immune response
title_full	Impact of proton therapy on antitumor immune response
title_fullStr	Impact of proton therapy on antitumor immune response
title_full_unstemmed	Impact of proton therapy on antitumor immune response
title_sort	impact of proton therapy on antitumor immune response
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c06ec6e3d0548fbbddd6f3023616eb5
work_keys_str_mv	AT celinemirjolet impactofprotontherapyonantitumorimmuneresponse AT anaisnicol impactofprotontherapyonantitumorimmuneresponse AT emericlimagne impactofprotontherapyonantitumorimmuneresponse AT carolemura impactofprotontherapyonantitumorimmuneresponse AT corentinrichard impactofprotontherapyonantitumorimmuneresponse AT veroniquemorgand impactofprotontherapyonantitumorimmuneresponse AT marcrousseau impactofprotontherapyonantitumorimmuneresponse AT romainboidot impactofprotontherapyonantitumorimmuneresponse AT francoisghiringhelli impactofprotontherapyonantitumorimmuneresponse AT georgesnoel impactofprotontherapyonantitumorimmuneresponse AT heleneburckel impactofprotontherapyonantitumorimmuneresponse
_version_	1718384414809915392

Impact of proton therapy on antitumor immune response

Ejemplares similares