Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration

ABSTRACT The investigation of microbial community dynamics is hampered by low resolution, a lack of control, and a small number of replicates. These deficiencies can be tackled with defined communities grown under well-controlled conditions in high-throughput automated cultivation devices. Besides d...

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Autor principal:	Karoline Faust
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	community models data integration high-throughput cultivation microbial community dynamics microbial systems biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/6c078ea411fe494ab000e5fa0271260b
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spelling	oai:doaj.org-article:6c078ea411fe494ab000e5fa0271260b2021-12-02T19:47:35ZTowards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration10.1128/mSystems.00101-192379-5077https://doaj.org/article/6c078ea411fe494ab000e5fa0271260b2019-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00101-19https://doaj.org/toc/2379-5077ABSTRACT The investigation of microbial community dynamics is hampered by low resolution, a lack of control, and a small number of replicates. These deficiencies can be tackled with defined communities grown under well-controlled conditions in high-throughput automated cultivation devices. Besides delivering high-quality microbial community data, automated cultivation will also ease measurement of the basic parameters needed to parameterize mathematical models of microbial communities. Better experimental data will allow revisiting classical ecological questions, such as the impact of community structure on dynamics. In addition, such data will allow validation and comparison of community models and benchmarking of microbial data analysis software. In summary, high-throughput automated cultivation will lead to a deeper understanding of microbial community dynamics through better models and software.Karoline FaustAmerican Society for Microbiologyarticlecommunity modelsdata integrationhigh-throughput cultivationmicrobial community dynamicsmicrobial systems biologyMicrobiologyQR1-502ENmSystems, Vol 4, Iss 3 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	community models data integration high-throughput cultivation microbial community dynamics microbial systems biology Microbiology QR1-502
spellingShingle	community models data integration high-throughput cultivation microbial community dynamics microbial systems biology Microbiology QR1-502 Karoline Faust Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration
description	ABSTRACT The investigation of microbial community dynamics is hampered by low resolution, a lack of control, and a small number of replicates. These deficiencies can be tackled with defined communities grown under well-controlled conditions in high-throughput automated cultivation devices. Besides delivering high-quality microbial community data, automated cultivation will also ease measurement of the basic parameters needed to parameterize mathematical models of microbial communities. Better experimental data will allow revisiting classical ecological questions, such as the impact of community structure on dynamics. In addition, such data will allow validation and comparison of community models and benchmarking of microbial data analysis software. In summary, high-throughput automated cultivation will lead to a deeper understanding of microbial community dynamics through better models and software.
format	article
author	Karoline Faust
author_facet	Karoline Faust
author_sort	Karoline Faust
title	Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration
title_short	Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration
title_full	Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration
title_fullStr	Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration
title_full_unstemmed	Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration
title_sort	towards a better understanding of microbial community dynamics through high-throughput cultivation and data integration
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/6c078ea411fe494ab000e5fa0271260b
work_keys_str_mv	AT karolinefaust towardsabetterunderstandingofmicrobialcommunitydynamicsthroughhighthroughputcultivationanddataintegration
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Towards a Better Understanding of Microbial Community Dynamics through High-Throughput Cultivation and Data Integration

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