Using CRISPR to understand how cancer mutations happen

Somatic mutations in cancer genomes can be caused by many different mutational processes, each of which produce distinctive patterns termed “mutational signatures”. Although cancer researchers can now recognize a large number of mutational signatures, exactly how these patterns arise remains unknown...

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Autor principal:	Eve H. Rogers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6c0d22112dca4591a1b37482add80220
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spelling	oai:doaj.org-article:6c0d22112dca4591a1b37482add802202021-12-02T18:02:49ZUsing CRISPR to understand how cancer mutations happen10.1038/s42003-021-02313-92399-3642https://doaj.org/article/6c0d22112dca4591a1b37482add802202021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02313-9https://doaj.org/toc/2399-3642Somatic mutations in cancer genomes can be caused by many different mutational processes, each of which produce distinctive patterns termed “mutational signatures”. Although cancer researchers can now recognize a large number of mutational signatures, exactly how these patterns arise remains unknown. Nik-Zainal and colleagues tackled this problem using a CRISPR-Cas9 genome editing screen to knock out components of the DNA mismatch repair machinery and learn their unique mutational patterns. Based on their data, the authors developed MMRDetect, a computational algorithm to classify the different DNA repair deficiencies and predict tumour responsiveness to immunotherapy.Eve H. RogersNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Eve H. Rogers Using CRISPR to understand how cancer mutations happen
description	Somatic mutations in cancer genomes can be caused by many different mutational processes, each of which produce distinctive patterns termed “mutational signatures”. Although cancer researchers can now recognize a large number of mutational signatures, exactly how these patterns arise remains unknown. Nik-Zainal and colleagues tackled this problem using a CRISPR-Cas9 genome editing screen to knock out components of the DNA mismatch repair machinery and learn their unique mutational patterns. Based on their data, the authors developed MMRDetect, a computational algorithm to classify the different DNA repair deficiencies and predict tumour responsiveness to immunotherapy.
format	article
author	Eve H. Rogers
author_facet	Eve H. Rogers
author_sort	Eve H. Rogers
title	Using CRISPR to understand how cancer mutations happen
title_short	Using CRISPR to understand how cancer mutations happen
title_full	Using CRISPR to understand how cancer mutations happen
title_fullStr	Using CRISPR to understand how cancer mutations happen
title_full_unstemmed	Using CRISPR to understand how cancer mutations happen
title_sort	using crispr to understand how cancer mutations happen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c0d22112dca4591a1b37482add80220
work_keys_str_mv	AT evehrogers usingcrisprtounderstandhowcancermutationshappen
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Using CRISPR to understand how cancer mutations happen

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