Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis

Background. Despite the known trigger and identified risk factors, the screening program developed, many aspects of the pathogenesis of cervical cancer are still being studied. In particular, recently in the literature there are data on the participation of short-chain fatty acids in the tumor proce...

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Autores principales:	E. V. Kayukova, T. E. Belokrinitskaya, L. F. Sholokhov, P. P. Tereshkov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	short-chain fatty acids tnf-α apoptosis cell cycle cervical cancer Science Q
Acceso en línea:	https://doaj.org/article/6c0fbb612a784c0d9ace59455036b58a
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spelling	oai:doaj.org-article:6c0fbb612a784c0d9ace59455036b58a2021-11-23T06:14:40ZFeatures of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis2541-94202587-959610.29413/ABS.2018-3.3.22https://doaj.org/article/6c0fbb612a784c0d9ace59455036b58a2018-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/598https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Despite the known trigger and identified risk factors, the screening program developed, many aspects of the pathogenesis of cervical cancer are still being studied. In particular, recently in the literature there are data on the participation of short-chain fatty acids in the tumor process. The aim of the study was to perform a correlation analysis of the level of TNF-A., its soluble sTNF-RI receptor, the spectrum of SCFA and some biological parameters (apoptosis, necrosis, proliferation, cell cycle) in the exocervical cells during dys- and neoplastic transformation. Materials and methods: the laboratory data obtained by us earlier were used to perform the Spearman correlation analysis. The groups of research: IA - the focus of the pre-tumor lesion of exocervix; IB - paradysplastic cells; IIA - locus of cervical cancer; IIB - paraneoplastic cells. Results. The correlation relationships between the parameters studied were multidirectional, determined by the state of the cell (healthy, dysplastic, malignant) and varied within one study, depending on the location in relation to the pathological focus. Conclusions. The revealed interrelations are important for expanding the already available information on cervical carcinogenesis, for discovery of new diagnostic methods and treatment of cervical neoplasia. Summarizing, it is possible to judge the presence of pathogenetic relationships between the processes of cervical carcinogenesis (proliferation, apoptosis, necrosis, modulation of the phases of the cell cycle), the level of short-chain fatty acids and cytokine production at the local level.E. V. KayukovaT. E. BelokrinitskayaL. F. SholokhovP. P. TereshkovScientific Сentre for Family Health and Human Reproduction Problemsarticleshort-chain fatty acidstnf-αapoptosiscell cyclecervical cancerScienceQRUActa Biomedica Scientifica, Vol 3, Iss 3, Pp 143-148 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	short-chain fatty acids tnf-α apoptosis cell cycle cervical cancer Science Q
spellingShingle	short-chain fatty acids tnf-α apoptosis cell cycle cervical cancer Science Q E. V. Kayukova T. E. Belokrinitskaya L. F. Sholokhov P. P. Tereshkov Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
description	Background. Despite the known trigger and identified risk factors, the screening program developed, many aspects of the pathogenesis of cervical cancer are still being studied. In particular, recently in the literature there are data on the participation of short-chain fatty acids in the tumor process. The aim of the study was to perform a correlation analysis of the level of TNF-A., its soluble sTNF-RI receptor, the spectrum of SCFA and some biological parameters (apoptosis, necrosis, proliferation, cell cycle) in the exocervical cells during dys- and neoplastic transformation. Materials and methods: the laboratory data obtained by us earlier were used to perform the Spearman correlation analysis. The groups of research: IA - the focus of the pre-tumor lesion of exocervix; IB - paradysplastic cells; IIA - locus of cervical cancer; IIB - paraneoplastic cells. Results. The correlation relationships between the parameters studied were multidirectional, determined by the state of the cell (healthy, dysplastic, malignant) and varied within one study, depending on the location in relation to the pathological focus. Conclusions. The revealed interrelations are important for expanding the already available information on cervical carcinogenesis, for discovery of new diagnostic methods and treatment of cervical neoplasia. Summarizing, it is possible to judge the presence of pathogenetic relationships between the processes of cervical carcinogenesis (proliferation, apoptosis, necrosis, modulation of the phases of the cell cycle), the level of short-chain fatty acids and cytokine production at the local level.
format	article
author	E. V. Kayukova T. E. Belokrinitskaya L. F. Sholokhov P. P. Tereshkov
author_facet	E. V. Kayukova T. E. Belokrinitskaya L. F. Sholokhov P. P. Tereshkov
author_sort	E. V. Kayukova
title	Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
title_short	Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
title_full	Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
title_fullStr	Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
title_full_unstemmed	Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
title_sort	features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/6c0fbb612a784c0d9ace59455036b58a
work_keys_str_mv	AT evkayukova featuresoftheinterrelationshipsofsomemolecularparametersofcervicalepitheliumcellswithbiologicalcharacteristicsoftumorcellsintheprocessofcervicalcarcinogenesis AT tebelokrinitskaya featuresoftheinterrelationshipsofsomemolecularparametersofcervicalepitheliumcellswithbiologicalcharacteristicsoftumorcellsintheprocessofcervicalcarcinogenesis AT lfsholokhov featuresoftheinterrelationshipsofsomemolecularparametersofcervicalepitheliumcellswithbiologicalcharacteristicsoftumorcellsintheprocessofcervicalcarcinogenesis AT pptereshkov featuresoftheinterrelationshipsofsomemolecularparametersofcervicalepitheliumcellswithbiologicalcharacteristicsoftumorcellsintheprocessofcervicalcarcinogenesis
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Features of the interrelationships of some molecular parameters of cervical epithelium cells with biological characteristics of tumor cells in the process of cervical carcinogenesis

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