CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution

Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespa...

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Autores principales: Qinchuan Wang, Erick O. Hernández-Ochoa, Meera C. Viswanathan, Ian D. Blum, Danh C. Do, Jonathan M. Granger, Kevin R. Murphy, An-Chi Wei, Susan Aja, Naili Liu, Corina M. Antonescu, Liliana D. Florea, C. Conover Talbot, David Mohr, Kathryn R. Wagner, Sergi Regot, Richard M. Lovering, Peisong Gao, Mario A. Bianchet, Mark N. Wu, Anthony Cammarato, Martin F. Schneider, Gabriel S. Bever, Mark E. Anderson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/6c13420d75db4c89a9f1e7180f0d0576
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Sumario:Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan.

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