CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespa...
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Nature Portfolio
2021
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oai:doaj.org-article:6c13420d75db4c89a9f1e7180f0d05762021-12-02T14:49:15ZCaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution10.1038/s41467-021-23549-32041-1723https://doaj.org/article/6c13420d75db4c89a9f1e7180f0d05762021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23549-3https://doaj.org/toc/2041-1723Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan.Qinchuan WangErick O. Hernández-OchoaMeera C. ViswanathanIan D. BlumDanh C. DoJonathan M. GrangerKevin R. MurphyAn-Chi WeiSusan AjaNaili LiuCorina M. AntonescuLiliana D. FloreaC. Conover TalbotDavid MohrKathryn R. WagnerSergi RegotRichard M. LoveringPeisong GaoMario A. BianchetMark N. WuAnthony CammaratoMartin F. SchneiderGabriel S. BeverMark E. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qinchuan Wang Erick O. Hernández-Ochoa Meera C. Viswanathan Ian D. Blum Danh C. Do Jonathan M. Granger Kevin R. Murphy An-Chi Wei Susan Aja Naili Liu Corina M. Antonescu Liliana D. Florea C. Conover Talbot David Mohr Kathryn R. Wagner Sergi Regot Richard M. Lovering Peisong Gao Mario A. Bianchet Mark N. Wu Anthony Cammarato Martin F. Schneider Gabriel S. Bever Mark E. Anderson CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| description |
Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan. |
| format |
article |
| author |
Qinchuan Wang Erick O. Hernández-Ochoa Meera C. Viswanathan Ian D. Blum Danh C. Do Jonathan M. Granger Kevin R. Murphy An-Chi Wei Susan Aja Naili Liu Corina M. Antonescu Liliana D. Florea C. Conover Talbot David Mohr Kathryn R. Wagner Sergi Regot Richard M. Lovering Peisong Gao Mario A. Bianchet Mark N. Wu Anthony Cammarato Martin F. Schneider Gabriel S. Bever Mark E. Anderson |
| author_facet |
Qinchuan Wang Erick O. Hernández-Ochoa Meera C. Viswanathan Ian D. Blum Danh C. Do Jonathan M. Granger Kevin R. Murphy An-Chi Wei Susan Aja Naili Liu Corina M. Antonescu Liliana D. Florea C. Conover Talbot David Mohr Kathryn R. Wagner Sergi Regot Richard M. Lovering Peisong Gao Mario A. Bianchet Mark N. Wu Anthony Cammarato Martin F. Schneider Gabriel S. Bever Mark E. Anderson |
| author_sort |
Qinchuan Wang |
| title |
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| title_short |
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| title_full |
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| title_fullStr |
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| title_full_unstemmed |
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| title_sort |
camkii oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/6c13420d75db4c89a9f1e7180f0d0576 |
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