Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa

Naoki Tojo, Tomoko Nakamura, Chiharu Fuchizawa, Toshihiko Oiwake, Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanBackground: The purpose of this study was to examine cone photoreceptors in the macula of patients...

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Autores principales:	Tojo N, Nakamura T, Fuchizawa C, Oiwake T, Hayashi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6c14166ca322415daa36c4167bddd8dc
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spelling	oai:doaj.org-article:6c14166ca322415daa36c4167bddd8dc2021-12-02T06:24:16ZAdaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa1177-54671177-5483https://doaj.org/article/6c14166ca322415daa36c4167bddd8dc2013-01-01T00:00:00Zhttp://www.dovepress.com/adaptive-optics-fundus-images-of-cone-photoreceptors-in-the-macula-of--a12047https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Naoki Tojo, Tomoko Nakamura, Chiharu Fuchizawa, Toshihiko Oiwake, Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanBackground: The purpose of this study was to examine cone photoreceptors in the macula of patients with retinitis pigmentosa using an adaptive optics fundus camera and to investigate any correlations between cone photoreceptor density and findings on optical coherence tomography and fundus autofluorescence.Methods: We examined two patients with typical retinitis pigmentosa who underwent ophthalmological examination, including measurement of visual acuity, and gathering of electroretinographic, optical coherence tomographic, fundus autofluorescent, and adaptive optics fundus images. The cone photoreceptors in the adaptive optics images of the two patients with retinitis pigmentosa and five healthy subjects were analyzed.Results: An abnormal parafoveal ring of high-density fundus autofluorescence was observed in the macula in both patients. The border of the ring corresponded to the border of the external limiting membrane and the inner segment and outer segment line in the optical coherence tomographic images. Cone photoreceptors at the abnormal parafoveal ring were blurred and decreased in the adaptive optics images. The blurred area corresponded to the abnormal parafoveal ring in the fundus autofluorescence images. Cone densities were low at the blurred areas and at the nasal and temporal retina along a line from the fovea compared with those of healthy controls. The results for cone spacing and Voronoi domains in the macula corresponded with those for the cone densities.Conclusion: Cone densities were heavily decreased in the macula, especially at the parafoveal ring on high-density fundus autofluorescence in both patients with retinitis pigmentosa. Adaptive optics images enabled us to observe in vivo changes in the cone photoreceptors of patients with retinitis pigmentosa, which corresponded to changes in the optical coherence tomographic and fundus autofluorescence images.Keywords: adaptive optics fundus camera, cone photoreceptor, fundus autofluorescence, optical coherence tomography, retinitis pigmentosaTojo NNakamura TFuchizawa COiwake THayashi ADove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 203-210 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tojo N Nakamura T Fuchizawa C Oiwake T Hayashi A Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
description	Naoki Tojo, Tomoko Nakamura, Chiharu Fuchizawa, Toshihiko Oiwake, Atsushi HayashiDepartment of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, JapanBackground: The purpose of this study was to examine cone photoreceptors in the macula of patients with retinitis pigmentosa using an adaptive optics fundus camera and to investigate any correlations between cone photoreceptor density and findings on optical coherence tomography and fundus autofluorescence.Methods: We examined two patients with typical retinitis pigmentosa who underwent ophthalmological examination, including measurement of visual acuity, and gathering of electroretinographic, optical coherence tomographic, fundus autofluorescent, and adaptive optics fundus images. The cone photoreceptors in the adaptive optics images of the two patients with retinitis pigmentosa and five healthy subjects were analyzed.Results: An abnormal parafoveal ring of high-density fundus autofluorescence was observed in the macula in both patients. The border of the ring corresponded to the border of the external limiting membrane and the inner segment and outer segment line in the optical coherence tomographic images. Cone photoreceptors at the abnormal parafoveal ring were blurred and decreased in the adaptive optics images. The blurred area corresponded to the abnormal parafoveal ring in the fundus autofluorescence images. Cone densities were low at the blurred areas and at the nasal and temporal retina along a line from the fovea compared with those of healthy controls. The results for cone spacing and Voronoi domains in the macula corresponded with those for the cone densities.Conclusion: Cone densities were heavily decreased in the macula, especially at the parafoveal ring on high-density fundus autofluorescence in both patients with retinitis pigmentosa. Adaptive optics images enabled us to observe in vivo changes in the cone photoreceptors of patients with retinitis pigmentosa, which corresponded to changes in the optical coherence tomographic and fundus autofluorescence images.Keywords: adaptive optics fundus camera, cone photoreceptor, fundus autofluorescence, optical coherence tomography, retinitis pigmentosa
format	article
author	Tojo N Nakamura T Fuchizawa C Oiwake T Hayashi A
author_facet	Tojo N Nakamura T Fuchizawa C Oiwake T Hayashi A
author_sort	Tojo N
title	Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
title_short	Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
title_full	Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
title_fullStr	Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
title_full_unstemmed	Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
title_sort	adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6c14166ca322415daa36c4167bddd8dc
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Adaptive optics fundus images of cone photoreceptors in the macula of patients with retinitis pigmentosa

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