Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer

The generation of α-carbon radicals from alkoxyl radicals is challenging because 1,2-hydrogen atom transfer (HAT) is usually less favoured than 1,5-HAT. Here, the authors report a strategy to inhibit 1,5-HAT by introducing a silyl group into the α-position of alkoxyl radicals, enabling preparation o...

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Autores principales:	Zhaoliang Yang, Yunhong Niu, Xiaoqian He, Suo Chen, Shanshan Liu, Zhengyu Li, Xiang Chen, Yunxiao Zhang, Yu Lan, Xiao Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c1a3b2d619d43439e674cec1a34b3bd
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spelling	oai:doaj.org-article:6c1a3b2d619d43439e674cec1a34b3bd2021-12-02T14:37:27ZTuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer10.1038/s41467-021-22382-y2041-1723https://doaj.org/article/6c1a3b2d619d43439e674cec1a34b3bd2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22382-yhttps://doaj.org/toc/2041-1723The generation of α-carbon radicals from alkoxyl radicals is challenging because 1,2-hydrogen atom transfer (HAT) is usually less favoured than 1,5-HAT. Here, the authors report a strategy to inhibit 1,5-HAT by introducing a silyl group into the α-position of alkoxyl radicals, enabling preparation of α-alkoxylimino alcohols and α-heteroaryl alcohols.Zhaoliang YangYunhong NiuXiaoqian HeSuo ChenShanshan LiuZhengyu LiXiang ChenYunxiao ZhangYu LanXiao ShenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhaoliang Yang Yunhong Niu Xiaoqian He Suo Chen Shanshan Liu Zhengyu Li Xiang Chen Yunxiao Zhang Yu Lan Xiao Shen Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
description	The generation of α-carbon radicals from alkoxyl radicals is challenging because 1,2-hydrogen atom transfer (HAT) is usually less favoured than 1,5-HAT. Here, the authors report a strategy to inhibit 1,5-HAT by introducing a silyl group into the α-position of alkoxyl radicals, enabling preparation of α-alkoxylimino alcohols and α-heteroaryl alcohols.
format	article
author	Zhaoliang Yang Yunhong Niu Xiaoqian He Suo Chen Shanshan Liu Zhengyu Li Xiang Chen Yunxiao Zhang Yu Lan Xiao Shen
author_facet	Zhaoliang Yang Yunhong Niu Xiaoqian He Suo Chen Shanshan Liu Zhengyu Li Xiang Chen Yunxiao Zhang Yu Lan Xiao Shen
author_sort	Zhaoliang Yang
title	Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
title_short	Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
title_full	Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
title_fullStr	Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
title_full_unstemmed	Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
title_sort	tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c1a3b2d619d43439e674cec1a34b3bd
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Tuning the reactivity of alkoxyl radicals from 1,5-hydrogen atom transfer to 1,2-silyl transfer

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