Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.

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Autores principales: Guizhi Zhu, Geoffrey M. Lynn, Orit Jacobson, Kai Chen, Yi Liu, Huimin Zhang, Ying Ma, Fuwu Zhang, Rui Tian, Qianqian Ni, Siyuan Cheng, Zhantong Wang, Nan Lu, Bryant C. Yung, Zhe Wang, Lixin Lang, Xiao Fu, Albert Jin, Ido D. Weiss, Harshad Vishwasrao, Gang Niu, Hari Shroff, Dennis M. Klinman, Robert A. Seder, Xiaoyuan Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/6c1cbd8acb2f42149db4a8201852deb6
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spelling oai:doaj.org-article:6c1cbd8acb2f42149db4a8201852deb62021-12-02T14:42:42ZAlbumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy10.1038/s41467-017-02191-y2041-1723https://doaj.org/article/6c1cbd8acb2f42149db4a8201852deb62017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02191-yhttps://doaj.org/toc/2041-1723Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.Guizhi ZhuGeoffrey M. LynnOrit JacobsonKai ChenYi LiuHuimin ZhangYing MaFuwu ZhangRui TianQianqian NiSiyuan ChengZhantong WangNan LuBryant C. YungZhe WangLixin LangXiao FuAlbert JinIdo D. WeissHarshad VishwasraoGang NiuHari ShroffDennis M. KlinmanRobert A. SederXiaoyuan ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Guizhi Zhu
Geoffrey M. Lynn
Orit Jacobson
Kai Chen
Yi Liu
Huimin Zhang
Ying Ma
Fuwu Zhang
Rui Tian
Qianqian Ni
Siyuan Cheng
Zhantong Wang
Nan Lu
Bryant C. Yung
Zhe Wang
Lixin Lang
Xiao Fu
Albert Jin
Ido D. Weiss
Harshad Vishwasrao
Gang Niu
Hari Shroff
Dennis M. Klinman
Robert A. Seder
Xiaoyuan Chen
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
description Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.
format article
author Guizhi Zhu
Geoffrey M. Lynn
Orit Jacobson
Kai Chen
Yi Liu
Huimin Zhang
Ying Ma
Fuwu Zhang
Rui Tian
Qianqian Ni
Siyuan Cheng
Zhantong Wang
Nan Lu
Bryant C. Yung
Zhe Wang
Lixin Lang
Xiao Fu
Albert Jin
Ido D. Weiss
Harshad Vishwasrao
Gang Niu
Hari Shroff
Dennis M. Klinman
Robert A. Seder
Xiaoyuan Chen
author_facet Guizhi Zhu
Geoffrey M. Lynn
Orit Jacobson
Kai Chen
Yi Liu
Huimin Zhang
Ying Ma
Fuwu Zhang
Rui Tian
Qianqian Ni
Siyuan Cheng
Zhantong Wang
Nan Lu
Bryant C. Yung
Zhe Wang
Lixin Lang
Xiao Fu
Albert Jin
Ido D. Weiss
Harshad Vishwasrao
Gang Niu
Hari Shroff
Dennis M. Klinman
Robert A. Seder
Xiaoyuan Chen
author_sort Guizhi Zhu
title Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
title_short Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
title_full Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
title_fullStr Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
title_full_unstemmed Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
title_sort albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/6c1cbd8acb2f42149db4a8201852deb6
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