Systemic vascular resistance in cirrhosis: a predictor of severity?

Vinaya Gaduputi, Molham Abdulsamad, Sailaja Sakam, Naeem Abbas, Hassan Tariq, Ariyo IhimoyanBronx Lebanon Hospital Center, Department of Medicine, Bronx, NY, USABackground: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gaduputi V, Abdulsamad M, Sakam S, Abbas N, Tariq H, Ihimoyan A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/6c26de59e9cf41bcb504c236b276226e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c26de59e9cf41bcb504c236b276226e
record_format	dspace
spelling	oai:doaj.org-article:6c26de59e9cf41bcb504c236b276226e2021-12-02T02:34:20ZSystemic vascular resistance in cirrhosis: a predictor of severity?1179-1535https://doaj.org/article/6c26de59e9cf41bcb504c236b276226e2014-08-01T00:00:00Zhttp://www.dovepress.com/systemic-vascular-resistance-in-cirrhosis-a-predictor-of-severity-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535 Vinaya Gaduputi, Molham Abdulsamad, Sailaja Sakam, Naeem Abbas, Hassan Tariq, Ariyo IhimoyanBronx Lebanon Hospital Center, Department of Medicine, Bronx, NY, USABackground: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications.Methods: Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) and underwent echocardiography were included in this study. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores.Results: A total of 771 patients with a diagnosis of decompensated cirrhosis were included in the study. Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia.Conclusion: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia. Keywords: systemic vascular resistance, cirrhosis, Model for End-stage Liver Disease, scoring systems Gaduputi VAbdulsamad MSakam SAbbas NTariq HIhimoyan ADove Medical PressarticleDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol 2014, Iss default, Pp 95-101 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Gaduputi V Abdulsamad M Sakam S Abbas N Tariq H Ihimoyan A Systemic vascular resistance in cirrhosis: a predictor of severity?
description	Vinaya Gaduputi, Molham Abdulsamad, Sailaja Sakam, Naeem Abbas, Hassan Tariq, Ariyo IhimoyanBronx Lebanon Hospital Center, Department of Medicine, Bronx, NY, USABackground: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modifications.Methods: Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) and underwent echocardiography were included in this study. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores.Results: A total of 771 patients with a diagnosis of decompensated cirrhosis were included in the study. Two hundred and sixty-two patients were found to have a low sodium level (<135 mEq/L) and 509 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia.Conclusion: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia. Keywords: systemic vascular resistance, cirrhosis, Model for End-stage Liver Disease, scoring systems
format	article
author	Gaduputi V Abdulsamad M Sakam S Abbas N Tariq H Ihimoyan A
author_facet	Gaduputi V Abdulsamad M Sakam S Abbas N Tariq H Ihimoyan A
author_sort	Gaduputi V
title	Systemic vascular resistance in cirrhosis: a predictor of severity?
title_short	Systemic vascular resistance in cirrhosis: a predictor of severity?
title_full	Systemic vascular resistance in cirrhosis: a predictor of severity?
title_fullStr	Systemic vascular resistance in cirrhosis: a predictor of severity?
title_full_unstemmed	Systemic vascular resistance in cirrhosis: a predictor of severity?
title_sort	systemic vascular resistance in cirrhosis: a predictor of severity?
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/6c26de59e9cf41bcb504c236b276226e
work_keys_str_mv	AT gaduputiv systemicvascularresistanceincirrhosisapredictorofseverity AT abdulsamadm systemicvascularresistanceincirrhosisapredictorofseverity AT sakams systemicvascularresistanceincirrhosisapredictorofseverity AT abbasn systemicvascularresistanceincirrhosisapredictorofseverity AT tariqh systemicvascularresistanceincirrhosisapredictorofseverity AT ihimoyana systemicvascularresistanceincirrhosisapredictorofseverity
_version_	1718402355836223488

Systemic vascular resistance in cirrhosis: a predictor of severity?

Ejemplares similares