ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.

ZBED genes originate from domesticated hAT DNA transposons and encode regulatory proteins of diverse function in vertebrates. Here we reveal the evolutionary relationship between ZBED genes and demonstrate that they are derived from at least two independent domestication events in jawed vertebrate a...

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Autores principales:	Alexander Hayward, Awaisa Ghazal, Göran Andersson, Leif Andersson, Patric Jern
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c27c68726b543079971a3f6bfc820f8
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spelling	oai:doaj.org-article:6c27c68726b543079971a3f6bfc820f82021-11-18T07:52:13ZZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.1932-620310.1371/journal.pone.0059940https://doaj.org/article/6c27c68726b543079971a3f6bfc820f82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23533661/?tool=EBIhttps://doaj.org/toc/1932-6203ZBED genes originate from domesticated hAT DNA transposons and encode regulatory proteins of diverse function in vertebrates. Here we reveal the evolutionary relationship between ZBED genes and demonstrate that they are derived from at least two independent domestication events in jawed vertebrate ancestors. We show that ZBEDs form two monophyletic clades, one of which has expanded through several independent duplications in host lineages. Subsequent diversification of ZBED genes has facilitated regulation of multiple diverse fundamental functions. In contrast to known examples of transposable element exaptation, our results demonstrate a novel unprecedented capacity for the repeated utilization of a family of transposable element-derived protein domains sequestered as regulators during the evolution of diverse host gene functions in vertebrates. Specifically, ZBEDs have contributed to vertebrate regulatory innovation through the donation of modular DNA and protein interacting domains. We identify that C7ORF29, ZBED2, 3, 4, and ZBEDX form a monophyletic group together with ZBED6, that is distinct from ZBED1 genes. Furthermore, we show that ZBED5 is related to Buster DNA transposons and is phylogenetically separate from other ZBEDs. Our results offer new insights into the evolution of regulatory pathways, and suggest that DNA transposons have contributed to regulatory complexity during genome evolution in vertebrates.Alexander HaywardAwaisa GhazalGöran AnderssonLeif AnderssonPatric JernPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59940 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexander Hayward Awaisa Ghazal Göran Andersson Leif Andersson Patric Jern ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
description	ZBED genes originate from domesticated hAT DNA transposons and encode regulatory proteins of diverse function in vertebrates. Here we reveal the evolutionary relationship between ZBED genes and demonstrate that they are derived from at least two independent domestication events in jawed vertebrate ancestors. We show that ZBEDs form two monophyletic clades, one of which has expanded through several independent duplications in host lineages. Subsequent diversification of ZBED genes has facilitated regulation of multiple diverse fundamental functions. In contrast to known examples of transposable element exaptation, our results demonstrate a novel unprecedented capacity for the repeated utilization of a family of transposable element-derived protein domains sequestered as regulators during the evolution of diverse host gene functions in vertebrates. Specifically, ZBEDs have contributed to vertebrate regulatory innovation through the donation of modular DNA and protein interacting domains. We identify that C7ORF29, ZBED2, 3, 4, and ZBEDX form a monophyletic group together with ZBED6, that is distinct from ZBED1 genes. Furthermore, we show that ZBED5 is related to Buster DNA transposons and is phylogenetically separate from other ZBEDs. Our results offer new insights into the evolution of regulatory pathways, and suggest that DNA transposons have contributed to regulatory complexity during genome evolution in vertebrates.
format	article
author	Alexander Hayward Awaisa Ghazal Göran Andersson Leif Andersson Patric Jern
author_facet	Alexander Hayward Awaisa Ghazal Göran Andersson Leif Andersson Patric Jern
author_sort	Alexander Hayward
title	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
title_short	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
title_full	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
title_fullStr	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
title_full_unstemmed	ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.
title_sort	zbed evolution: repeated utilization of dna transposons as regulators of diverse host functions.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/6c27c68726b543079971a3f6bfc820f8
work_keys_str_mv	AT alexanderhayward zbedevolutionrepeatedutilizationofdnatransposonsasregulatorsofdiversehostfunctions AT awaisaghazal zbedevolutionrepeatedutilizationofdnatransposonsasregulatorsofdiversehostfunctions AT goranandersson zbedevolutionrepeatedutilizationofdnatransposonsasregulatorsofdiversehostfunctions AT leifandersson zbedevolutionrepeatedutilizationofdnatransposonsasregulatorsofdiversehostfunctions AT patricjern zbedevolutionrepeatedutilizationofdnatransposonsasregulatorsofdiversehostfunctions
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ZBED evolution: repeated utilization of DNA transposons as regulators of diverse host functions.

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