The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats

Deltamethrin (DLM) is a synthetic pyrethroid type-II known to cause many adverse effects in experimental animals such as endocrine disruption, reproductive toxicity, and negative impact on gametogenesis. The present study was conducted to evaluate the protective role of wheat germ oil against reprod...

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Autores principales:	Abeer M. Radi, Naglaa M. Abdel-Azeem, Ismail Mostafa, Nermeen A. Helmy, Walaa M.S. Ahmed
Formato:	article
Lenguaje:	EN
Publicado:	Egyptian Society for Animal Management 2021
Materias:	deltamethrin dna fragmentation male fertility wheat germ oil Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
Acceso en línea:	https://doaj.org/article/6c2a30963ba64981ba252e813db985fa
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spelling	oai:doaj.org-article:6c2a30963ba64981ba252e813db985fa2021-12-02T16:14:22ZThe Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats10.21608/javs.2021.80220.10851687-40722090-3308https://doaj.org/article/6c2a30963ba64981ba252e813db985fa2021-07-01T00:00:00Zhttps://javs.journals.ekb.eg/article_184144.htmlhttps://doaj.org/toc/1687-4072https://doaj.org/toc/2090-3308Deltamethrin (DLM) is a synthetic pyrethroid type-II known to cause many adverse effects in experimental animals such as endocrine disruption, reproductive toxicity, and negative impact on gametogenesis. The present study was conducted to evaluate the protective role of wheat germ oil against reproductive toxicity induced by Deltamethrin (DLM) in male albino rats through evaluation of semen picture, measuring the testosterone levels, DNA fragmentation percentage and pathologic changes of the testes. Thirty male rats were divided into three groups (10 each); the first group (C) was administered with normal saline, the second group was given (DLM) at a dose of (6 mg/kg. B.W. of rats) and the third group (DLM+WGO) was treated with wheat germ oil (1.5 ml/Kg. B.W. of rats), and after one h DLM (6 mg/kg. B.W. of rats) was administered. All treatments were orally given using stomach gavage for 30 days. The rats were left for 65 days of treatment to complete time of one spermatogenesis and maturation of sperms in epididymis then sacrificed and blood samples were collected, testes and epididymis were removed, weighted, and examined histopathologically. DLM administration significantly decreased the weight of testes and adversely affected the semen quality. Testosterone levels were significantly reduced. There is a significant elevation in the DNA laddering percentage in the DLM group compared to the C group. Histopathological examination of the testes revealed that DLM induced changes in the form of distorted seminiferous tubules with intraluminal sloughing degenerated spermatogenic cells. Also there is marked interstitial edema and congestion. The co-administration of DLM with wheat germ showed improvement in weight of testes, semen pictures, testosterone level and a significant reduction in the DNA laddering percentage compared to DLM group. It can be concluded that, the wheat germ oil can mitigate the adverse effects of DLM on male fertility, and leads to improvement of male reproductive performance. Abeer M. RadiNaglaa M. Abdel-AzeemIsmail MostafaNermeen A. HelmyWalaa M.S. AhmedEgyptian Society for Animal Managementarticledeltamethrindna fragmentationmale fertilitywheat germ oilZoologyQL1-991Veterinary medicineSF600-1100Animal biochemistryQP501-801ENJournal of Applied Veterinary Sciences, Vol 6, Iss 3, Pp 70-75 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	deltamethrin dna fragmentation male fertility wheat germ oil Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801
spellingShingle	deltamethrin dna fragmentation male fertility wheat germ oil Zoology QL1-991 Veterinary medicine SF600-1100 Animal biochemistry QP501-801 Abeer M. Radi Naglaa M. Abdel-Azeem Ismail Mostafa Nermeen A. Helmy Walaa M.S. Ahmed The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats
description	Deltamethrin (DLM) is a synthetic pyrethroid type-II known to cause many adverse effects in experimental animals such as endocrine disruption, reproductive toxicity, and negative impact on gametogenesis. The present study was conducted to evaluate the protective role of wheat germ oil against reproductive toxicity induced by Deltamethrin (DLM) in male albino rats through evaluation of semen picture, measuring the testosterone levels, DNA fragmentation percentage and pathologic changes of the testes. Thirty male rats were divided into three groups (10 each); the first group (C) was administered with normal saline, the second group was given (DLM) at a dose of (6 mg/kg. B.W. of rats) and the third group (DLM+WGO) was treated with wheat germ oil (1.5 ml/Kg. B.W. of rats), and after one h DLM (6 mg/kg. B.W. of rats) was administered. All treatments were orally given using stomach gavage for 30 days. The rats were left for 65 days of treatment to complete time of one spermatogenesis and maturation of sperms in epididymis then sacrificed and blood samples were collected, testes and epididymis were removed, weighted, and examined histopathologically. DLM administration significantly decreased the weight of testes and adversely affected the semen quality. Testosterone levels were significantly reduced. There is a significant elevation in the DNA laddering percentage in the DLM group compared to the C group. Histopathological examination of the testes revealed that DLM induced changes in the form of distorted seminiferous tubules with intraluminal sloughing degenerated spermatogenic cells. Also there is marked interstitial edema and congestion. The co-administration of DLM with wheat germ showed improvement in weight of testes, semen pictures, testosterone level and a significant reduction in the DNA laddering percentage compared to DLM group. It can be concluded that, the wheat germ oil can mitigate the adverse effects of DLM on male fertility, and leads to improvement of male reproductive performance.
format	article
author	Abeer M. Radi Naglaa M. Abdel-Azeem Ismail Mostafa Nermeen A. Helmy Walaa M.S. Ahmed
author_facet	Abeer M. Radi Naglaa M. Abdel-Azeem Ismail Mostafa Nermeen A. Helmy Walaa M.S. Ahmed
author_sort	Abeer M. Radi
title	The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats
title_short	The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats
title_full	The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats
title_fullStr	The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats
title_full_unstemmed	The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats
title_sort	protective role of wheat germ oil against adverse effect of deltamethrin on reproductive aspects of male albino rats
publisher	Egyptian Society for Animal Management
publishDate	2021
url	https://doaj.org/article/6c2a30963ba64981ba252e813db985fa
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The Protective Role of Wheat Germ Oil against Adverse Effect of Deltamethrin on Reproductive Aspects of Male Albino Rats

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