Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the beneficial effects.

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Autores principales:	Kai Mao, Gabriela Farias Quipildor, Tahmineh Tabrizian, Ardijana Novaj, Fangxia Guan, Ryan O. Walters, Fabien Delahaye, Gene B. Hubbard, Yuji Ikeno, Keisuke Ejima, Peng Li, David B. Allison, Hossein Salimi-Moosavi, Pedro J. Beltran, Pinchas Cohen, Nir Barzilai, Derek M. Huffman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c2da7569db9463080f4475bda1b2e80
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spelling	oai:doaj.org-article:6c2da7569db9463080f4475bda1b2e802021-12-02T15:33:40ZLate-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice10.1038/s41467-018-04805-52041-1723https://doaj.org/article/6c2da7569db9463080f4475bda1b2e802018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04805-5https://doaj.org/toc/2041-1723Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the beneficial effects.Kai MaoGabriela Farias QuipildorTahmineh TabrizianArdijana NovajFangxia GuanRyan O. WaltersFabien DelahayeGene B. HubbardYuji IkenoKeisuke EjimaPeng LiDavid B. AllisonHossein Salimi-MoosaviPedro J. BeltranPinchas CohenNir BarzilaiDerek M. HuffmanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Mao Gabriela Farias Quipildor Tahmineh Tabrizian Ardijana Novaj Fangxia Guan Ryan O. Walters Fabien Delahaye Gene B. Hubbard Yuji Ikeno Keisuke Ejima Peng Li David B. Allison Hossein Salimi-Moosavi Pedro J. Beltran Pinchas Cohen Nir Barzilai Derek M. Huffman Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
description	Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the beneficial effects.
format	article
author	Kai Mao Gabriela Farias Quipildor Tahmineh Tabrizian Ardijana Novaj Fangxia Guan Ryan O. Walters Fabien Delahaye Gene B. Hubbard Yuji Ikeno Keisuke Ejima Peng Li David B. Allison Hossein Salimi-Moosavi Pedro J. Beltran Pinchas Cohen Nir Barzilai Derek M. Huffman
author_facet	Kai Mao Gabriela Farias Quipildor Tahmineh Tabrizian Ardijana Novaj Fangxia Guan Ryan O. Walters Fabien Delahaye Gene B. Hubbard Yuji Ikeno Keisuke Ejima Peng Li David B. Allison Hossein Salimi-Moosavi Pedro J. Beltran Pinchas Cohen Nir Barzilai Derek M. Huffman
author_sort	Kai Mao
title	Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
title_short	Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
title_full	Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
title_fullStr	Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
title_full_unstemmed	Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
title_sort	late-life targeting of the igf-1 receptor improves healthspan and lifespan in female mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/6c2da7569db9463080f4475bda1b2e80
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Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice

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