Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

Abstract Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea’s i...

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Autores principales:	Janani S. Iyer, Biwei Yin, Konstantina M. Stankovic, Guillermo J. Tearney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c30ce8dde154341a36e1e5434bfd213
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spelling	oai:doaj.org-article:6c30ce8dde154341a36e1e5434bfd2132021-12-02T17:19:15ZEndomicroscopy of the human cochlea using a micro-optical coherence tomography catheter10.1038/s41598-021-95991-82045-2322https://doaj.org/article/6c30ce8dde154341a36e1e5434bfd2132021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95991-8https://doaj.org/toc/2045-2322Abstract Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea’s inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear’s sensory epithelium in cadaveric human inner ears.Janani S. IyerBiwei YinKonstantina M. StankovicGuillermo J. TearneyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Janani S. Iyer Biwei Yin Konstantina M. Stankovic Guillermo J. Tearney Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
description	Abstract Sensorineural hearing loss (SNHL) is one of the most profound public health concerns of the modern era, affecting 466 million people today, and projected to affect 900 million by the year 2050. Advances in both diagnostics and therapeutics for SNHL have been impeded by the human cochlea’s inaccessibility for in vivo imaging, resulting from its extremely small size, convoluted coiled configuration, fragility, and deep encasement in dense bone. Here, we develop and demonstrate the ability of a sub-millimeter-diameter, flexible endoscopic probe interfaced with a micro-optical coherence tomography (μOCT) imaging system to enable micron-scale imaging of the inner ear’s sensory epithelium in cadaveric human inner ears.
format	article
author	Janani S. Iyer Biwei Yin Konstantina M. Stankovic Guillermo J. Tearney
author_facet	Janani S. Iyer Biwei Yin Konstantina M. Stankovic Guillermo J. Tearney
author_sort	Janani S. Iyer
title	Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
title_short	Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
title_full	Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
title_fullStr	Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
title_full_unstemmed	Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
title_sort	endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c30ce8dde154341a36e1e5434bfd213
work_keys_str_mv	AT jananisiyer endomicroscopyofthehumancochleausingamicroopticalcoherencetomographycatheter AT biweiyin endomicroscopyofthehumancochleausingamicroopticalcoherencetomographycatheter AT konstantinamstankovic endomicroscopyofthehumancochleausingamicroopticalcoherencetomographycatheter AT guillermojtearney endomicroscopyofthehumancochleausingamicroopticalcoherencetomographycatheter
_version_	1718381031138000896

Endomicroscopy of the human cochlea using a micro-optical coherence tomography catheter

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