F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

Endothelial cells can support leukocyte extravasation without causing vascular leakage, but the exact mechanism underlying this process has not been fully elucidated. Here the authors show that it is regulated through actomyosin-based endothelial pore confinement, which requires local endothelial Rh...

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Autores principales:	Niels Heemskerk, Lilian Schimmel, Chantal Oort, Jos van Rijssel, Taofei Yin, Bin Ma, Jakobus van Unen, Bettina Pitter, Stephan Huveneers, Joachim Goedhart, Yi Wu, Eloi Montanez, Abigail Woodfin, Jaap D. van Buul
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c3133e60cd84e1f9874b018a721bd0a
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spelling	oai:doaj.org-article:6c3133e60cd84e1f9874b018a721bd0a2021-12-02T15:34:10ZF-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling10.1038/ncomms104932041-1723https://doaj.org/article/6c3133e60cd84e1f9874b018a721bd0a2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10493https://doaj.org/toc/2041-1723Endothelial cells can support leukocyte extravasation without causing vascular leakage, but the exact mechanism underlying this process has not been fully elucidated. Here the authors show that it is regulated through actomyosin-based endothelial pore confinement, which requires local endothelial RhoA activation.Niels HeemskerkLilian SchimmelChantal OortJos van RijsselTaofei YinBin MaJakobus van UnenBettina PitterStephan HuveneersJoachim GoedhartYi WuEloi MontanezAbigail WoodfinJaap D. van BuulNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Niels Heemskerk Lilian Schimmel Chantal Oort Jos van Rijssel Taofei Yin Bin Ma Jakobus van Unen Bettina Pitter Stephan Huveneers Joachim Goedhart Yi Wu Eloi Montanez Abigail Woodfin Jaap D. van Buul F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
description	Endothelial cells can support leukocyte extravasation without causing vascular leakage, but the exact mechanism underlying this process has not been fully elucidated. Here the authors show that it is regulated through actomyosin-based endothelial pore confinement, which requires local endothelial RhoA activation.
format	article
author	Niels Heemskerk Lilian Schimmel Chantal Oort Jos van Rijssel Taofei Yin Bin Ma Jakobus van Unen Bettina Pitter Stephan Huveneers Joachim Goedhart Yi Wu Eloi Montanez Abigail Woodfin Jaap D. van Buul
author_facet	Niels Heemskerk Lilian Schimmel Chantal Oort Jos van Rijssel Taofei Yin Bin Ma Jakobus van Unen Bettina Pitter Stephan Huveneers Joachim Goedhart Yi Wu Eloi Montanez Abigail Woodfin Jaap D. van Buul
author_sort	Niels Heemskerk
title	F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
title_short	F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
title_full	F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
title_fullStr	F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
title_full_unstemmed	F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling
title_sort	f-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local rhoa signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6c3133e60cd84e1f9874b018a721bd0a
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F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling

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