A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases
With the Delta variant currently fueling a resurgence of new infections in the fully vaccinated population, developing an effective therapeutic drug is especially critical and urgent in fighting COVID-19. In contrast to the many efforts to repurpose existing drugs or address only one aspect of COVI...
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American Society for Microbiology
2021
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oai:doaj.org-article:6c3529ada1aa4bd78d4bef494a632d382021-11-03T21:52:35ZA Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases2150-751110.1128/mBio.02542-21https://doaj.org/article/6c3529ada1aa4bd78d4bef494a632d382021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02542-21https://doaj.org/toc/2150-7511 With the Delta variant currently fueling a resurgence of new infections in the fully vaccinated population, developing an effective therapeutic drug is especially critical and urgent in fighting COVID-19. In contrast to the many efforts to repurpose existing drugs or address only one aspect of COVID-19, we are developing a novel agent with first-in-class mechanisms of action that address both the viral infection and the overactive immune system in the pathogenesis of the disease.Zhizhen LiJianping WuJi ZhouBaoshi YuanJiqiao ChenWanchen WuLian MoZhipeng QuFei ZhouYingying DongKai HuangZhiwei LiuTao WangDeebie SymmesJingliang GuEiketsu ShoJingping ZhangRuihuan ChenYing XuAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Zhizhen Li Jianping Wu Ji Zhou Baoshi Yuan Jiqiao Chen Wanchen Wu Lian Mo Zhipeng Qu Fei Zhou Yingying Dong Kai Huang Zhiwei Liu Tao Wang Deebie Symmes Jingliang Gu Eiketsu Sho Jingping Zhang Ruihuan Chen Ying Xu A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases |
| description |
With the Delta variant currently fueling a resurgence of new infections in the fully vaccinated population, developing an effective therapeutic drug is especially critical and urgent in fighting COVID-19. In contrast to the many efforts to repurpose existing drugs or address only one aspect of COVID-19, we are developing a novel agent with first-in-class mechanisms of action that address both the viral infection and the overactive immune system in the pathogenesis of the disease. |
| format |
article |
| author |
Zhizhen Li Jianping Wu Ji Zhou Baoshi Yuan Jiqiao Chen Wanchen Wu Lian Mo Zhipeng Qu Fei Zhou Yingying Dong Kai Huang Zhiwei Liu Tao Wang Deebie Symmes Jingliang Gu Eiketsu Sho Jingping Zhang Ruihuan Chen Ying Xu |
| author_facet |
Zhizhen Li Jianping Wu Ji Zhou Baoshi Yuan Jiqiao Chen Wanchen Wu Lian Mo Zhipeng Qu Fei Zhou Yingying Dong Kai Huang Zhiwei Liu Tao Wang Deebie Symmes Jingliang Gu Eiketsu Sho Jingping Zhang Ruihuan Chen Ying Xu |
| author_sort |
Zhizhen Li |
| title |
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases |
| title_short |
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases |
| title_full |
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases |
| title_fullStr |
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases |
| title_full_unstemmed |
A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases |
| title_sort |
vimentin-targeting oral compound with host-directed antiviral and anti-inflammatory actions addresses multiple features of covid-19 and related diseases |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/6c3529ada1aa4bd78d4bef494a632d38 |
| work_keys_str_mv |
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