Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese mice.

Preservation of metabolic flexibility in skeletal muscle by a combined use of n-3 PUFA and rosiglitazone in dietary obese mice.

Insulin resistance, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. This, in turn, contributes to a further damage of insulin signaling. Effectiveness of T2D treatment depends in large part on the...

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Autores principales: Olga Horakova, Dasa Medrikova, Evert M van Schothorst, Annelies Bunschoten, Pavel Flachs, Vladimir Kus, Ondrej Kuda, Kristina Bardova, Petra Janovska, Michal Hensler, Martin Rossmeisl, Rui Wang-Sattler, Cornelia Prehn, Jerzy Adamski, Thomas Illig, Jaap Keijer, Jan Kopecky
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6c369ad1fc064c589162e6d74ea2dcba
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