Astrocytic GABA transporter activity modulates excitatory neurotransmission

Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit ne...

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Autores principales:	Kim Boddum, Thomas P. Jensen, Vincent Magloire, Uffe Kristiansen, Dmitri A. Rusakov, Ivan Pavlov, Matthew C. Walker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c3a64f69f364f18a63aed2e76e83135
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spelling	oai:doaj.org-article:6c3a64f69f364f18a63aed2e76e831352021-12-02T16:57:04ZAstrocytic GABA transporter activity modulates excitatory neurotransmission10.1038/ncomms135722041-1723https://doaj.org/article/6c3a64f69f364f18a63aed2e76e831352016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13572https://doaj.org/toc/2041-1723Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit neural glutamatergic signalling.Kim BoddumThomas P. JensenVincent MagloireUffe KristiansenDmitri A. RusakovIvan PavlovMatthew C. WalkerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kim Boddum Thomas P. Jensen Vincent Magloire Uffe Kristiansen Dmitri A. Rusakov Ivan Pavlov Matthew C. Walker Astrocytic GABA transporter activity modulates excitatory neurotransmission
description	Astrocytes monitor and regulate both excitatory and inhibitory synaptic activity. Here, the authors identify a novel form of neuronal-glia communication, by which astrocytes detect rises in GABA via the GABA transporter GAT-3; this results in adenosine release that acts presynaptically to inhibit neural glutamatergic signalling.
format	article
author	Kim Boddum Thomas P. Jensen Vincent Magloire Uffe Kristiansen Dmitri A. Rusakov Ivan Pavlov Matthew C. Walker
author_facet	Kim Boddum Thomas P. Jensen Vincent Magloire Uffe Kristiansen Dmitri A. Rusakov Ivan Pavlov Matthew C. Walker
author_sort	Kim Boddum
title	Astrocytic GABA transporter activity modulates excitatory neurotransmission
title_short	Astrocytic GABA transporter activity modulates excitatory neurotransmission
title_full	Astrocytic GABA transporter activity modulates excitatory neurotransmission
title_fullStr	Astrocytic GABA transporter activity modulates excitatory neurotransmission
title_full_unstemmed	Astrocytic GABA transporter activity modulates excitatory neurotransmission
title_sort	astrocytic gaba transporter activity modulates excitatory neurotransmission
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6c3a64f69f364f18a63aed2e76e83135
work_keys_str_mv	AT kimboddum astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission AT thomaspjensen astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission AT vincentmagloire astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission AT uffekristiansen astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission AT dmitriarusakov astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission AT ivanpavlov astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission AT matthewcwalker astrocyticgabatransporteractivitymodulatesexcitatoryneurotransmission
_version_	1718382629766561792

Astrocytic GABA transporter activity modulates excitatory neurotransmission

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