Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience

Several retrospective analyses of large amounts of contemporary data have shown the superiority of breast conservative surgery (BCS) over mastectomy carried out in the early stage of breast cancer. The characteristics of the patients and cancers that are most likely to benefit from BCS remain unclea...

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Autores principales:	Annarita Fanizzi, Maurizio Cosmo Ressa, Gianluca Gatta, Cristian Cristofaro, Valerio De Santis, Vittorio Didonna, Sergio Diotaiuti, Daniele La Forgia, Nicole Petruzzellis, Pasquale Tamborra, Vito Lorusso, Raffaella Massafra
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	conservative breast surgery mastectomy quadrantectomy breast cancer disease-free survival early stage cancers T1-2 tumors Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6c3aa71138964786994664a7a256be39
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spelling	oai:doaj.org-article:6c3aa71138964786994664a7a256be392021-11-11T14:57:16ZDisease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience10.3390/app112198002076-3417https://doaj.org/article/6c3aa71138964786994664a7a256be392021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/21/9800https://doaj.org/toc/2076-3417Several retrospective analyses of large amounts of contemporary data have shown the superiority of breast conservative surgery (BCS) over mastectomy carried out in the early stage of breast cancer. The characteristics of the patients and cancers that are most likely to benefit from BCS remain unclear. In our work, we analyzed the disease-free survival (DFS) of a cohort of patients treated with BCS or mastectomy between 1995 and 2018 in our institute with pT1-2, pN0, or cM0 breast cancer. The DFS curves of patients treated with both mastectomy and quadrantectomy were compared in the different subsamples with respect to the clinical and histopathological characteristics. We identified 188 eligible patients treated with BCS and 64 patients treated with mastectomy. DFS was not found to be statistically higher in patients treated with BCS compared to those treated with mastectomy, who achieved a 5-year DFS of 89.9% vs. 81.3% and a 10-year DFS of 78.9% vs. 79.3%, respectively. No significant differences were detected for the DFS curves when patients were differentiated by the type of surgical treatment received, age, and the tumor histological characteristics. We verified a <i>p</i>-value just above the 10% significance threshold for patients with tumor dimensions between 20 mm and 50 mm and molecular sub-type Luminal B. In our experience, treatment with mastectomy is not associated with improved DFS compared to treatment with BCS in women with early-stage tumors.Annarita FanizziMaurizio Cosmo RessaGianluca GattaCristian CristofaroValerio De SantisVittorio DidonnaSergio DiotaiutiDaniele La ForgiaNicole PetruzzellisPasquale TamborraVito LorussoRaffaella MassafraMDPI AGarticleconservative breast surgerymastectomyquadrantectomybreast cancer disease-free survivalearly stage cancersT1-2 tumorsTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 9800, p 9800 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	conservative breast surgery mastectomy quadrantectomy breast cancer disease-free survival early stage cancers T1-2 tumors Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	conservative breast surgery mastectomy quadrantectomy breast cancer disease-free survival early stage cancers T1-2 tumors Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Annarita Fanizzi Maurizio Cosmo Ressa Gianluca Gatta Cristian Cristofaro Valerio De Santis Vittorio Didonna Sergio Diotaiuti Daniele La Forgia Nicole Petruzzellis Pasquale Tamborra Vito Lorusso Raffaella Massafra Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience
description	Several retrospective analyses of large amounts of contemporary data have shown the superiority of breast conservative surgery (BCS) over mastectomy carried out in the early stage of breast cancer. The characteristics of the patients and cancers that are most likely to benefit from BCS remain unclear. In our work, we analyzed the disease-free survival (DFS) of a cohort of patients treated with BCS or mastectomy between 1995 and 2018 in our institute with pT1-2, pN0, or cM0 breast cancer. The DFS curves of patients treated with both mastectomy and quadrantectomy were compared in the different subsamples with respect to the clinical and histopathological characteristics. We identified 188 eligible patients treated with BCS and 64 patients treated with mastectomy. DFS was not found to be statistically higher in patients treated with BCS compared to those treated with mastectomy, who achieved a 5-year DFS of 89.9% vs. 81.3% and a 10-year DFS of 78.9% vs. 79.3%, respectively. No significant differences were detected for the DFS curves when patients were differentiated by the type of surgical treatment received, age, and the tumor histological characteristics. We verified a <i>p</i>-value just above the 10% significance threshold for patients with tumor dimensions between 20 mm and 50 mm and molecular sub-type Luminal B. In our experience, treatment with mastectomy is not associated with improved DFS compared to treatment with BCS in women with early-stage tumors.
format	article
author	Annarita Fanizzi Maurizio Cosmo Ressa Gianluca Gatta Cristian Cristofaro Valerio De Santis Vittorio Didonna Sergio Diotaiuti Daniele La Forgia Nicole Petruzzellis Pasquale Tamborra Vito Lorusso Raffaella Massafra
author_facet	Annarita Fanizzi Maurizio Cosmo Ressa Gianluca Gatta Cristian Cristofaro Valerio De Santis Vittorio Didonna Sergio Diotaiuti Daniele La Forgia Nicole Petruzzellis Pasquale Tamborra Vito Lorusso Raffaella Massafra
author_sort	Annarita Fanizzi
title	Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience
title_short	Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience
title_full	Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience
title_fullStr	Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience
title_full_unstemmed	Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience
title_sort	disease-free survival after breast conservation therapy vs. mastectomy of patients with t1/2 breast cancer and no lymph node metastases: our experience
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6c3aa71138964786994664a7a256be39
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Disease-Free Survival after Breast Conservation Therapy vs. Mastectomy of Patients with T1/2 Breast Cancer and No Lymph Node Metastases: Our Experience

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