Molecular basis for PrimPol recruitment to replication forks by RPA

Molecular basis for PrimPol recruitment to replication forks by RPA

PrimPol is a multifunctional replicative enzyme that can bypass DNA damage, as well as reprime replication restart. Here, the authors have elucidated how PrimPol is recruited to stalled replication forks via specific interactions with RPA, which stimulates its primase activity.

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Detalles Bibliográficos
Autores principales: Thomas A. Guilliam, Nigel C. Brissett, Aaron Ehlinger, Benjamin A. Keen, Peter Kolesar, Elaine M. Taylor, Laura J. Bailey, Howard D. Lindsay, Walter J. Chazin, Aidan J. Doherty
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/6c3b35c0421a4ab2b8722df6acbdcac6
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