Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections

Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison...

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Autores principales:	Arsham Ghavasieh, Sebastiano Bontorin, Oriol Artime, Nina Verstraete, Manlio De Domenico
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Astrophysics QB460-466 Physics QC1-999
Acceso en línea:	https://doaj.org/article/6c3ec879512740d28f17babc13acf0d4
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spelling	oai:doaj.org-article:6c3ec879512740d28f17babc13acf0d42021-12-02T17:32:52ZMultiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections10.1038/s42005-021-00582-82399-3650https://doaj.org/article/6c3ec879512740d28f17babc13acf0d42021-04-01T00:00:00Zhttps://doi.org/10.1038/s42005-021-00582-8https://doaj.org/toc/2399-3650Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases.Arsham GhavasiehSebastiano BontorinOriol ArtimeNina VerstraeteManlio De DomenicoNature PortfolioarticleAstrophysicsQB460-466PhysicsQC1-999ENCommunications Physics, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Astrophysics QB460-466 Physics QC1-999
spellingShingle	Astrophysics QB460-466 Physics QC1-999 Arsham Ghavasieh Sebastiano Bontorin Oriol Artime Nina Verstraete Manlio De Domenico Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
description	Characterizing the interactions between viral and human proteins is key to understand the function and structure of viruses such as SARS-CoV-2 and for informing drug design and repurposing strategies. Here, the authors use statistical physics techniques to perform a systematic multiscale comparison of the effects on the human interactome of SARS-CoV-2 with respect to other viruses, and find that COVID-19 exhibits properties typical of systemic diseases.
format	article
author	Arsham Ghavasieh Sebastiano Bontorin Oriol Artime Nina Verstraete Manlio De Domenico
author_facet	Arsham Ghavasieh Sebastiano Bontorin Oriol Artime Nina Verstraete Manlio De Domenico
author_sort	Arsham Ghavasieh
title	Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_short	Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_full	Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_fullStr	Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_full_unstemmed	Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections
title_sort	multiscale statistical physics of the pan-viral interactome unravels the systemic nature of sars-cov-2 infections
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6c3ec879512740d28f17babc13acf0d4
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Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections

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