Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis

Endometriosis is a common gynaecological disease but the underlying pathogenesis is poorly understood, however there is a strong familial component. Here the authors conduct a genome wide association study and identify a novel susceptibility locus that correlates with disease severity.

Guardado en:

Detalles Bibliográficos
Autores principales:	Valgerdur Steinthorsdottir, Gudmar Thorleifsson, Kristrun Aradottir, Bjarke Feenstra, Asgeir Sigurdsson, Lilja Stefansdottir, Anna M. Kristinsdottir, Florian Zink, Gisli H. Halldorsson, Nete Munk Nielsen, Frank Geller, Mads Melbye, Daniel F. Gudbjartsson, Reynir T. Geirsson, Unnur Thorsteinsdottir, Kari Stefansson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c41abb3afba4f8a8463de22de52ead8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c41abb3afba4f8a8463de22de52ead8
record_format	dspace
spelling	oai:doaj.org-article:6c41abb3afba4f8a8463de22de52ead82021-12-02T16:57:02ZCommon variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis10.1038/ncomms123502041-1723https://doaj.org/article/6c41abb3afba4f8a8463de22de52ead82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12350https://doaj.org/toc/2041-1723Endometriosis is a common gynaecological disease but the underlying pathogenesis is poorly understood, however there is a strong familial component. Here the authors conduct a genome wide association study and identify a novel susceptibility locus that correlates with disease severity.Valgerdur SteinthorsdottirGudmar ThorleifssonKristrun AradottirBjarke FeenstraAsgeir SigurdssonLilja StefansdottirAnna M. KristinsdottirFlorian ZinkGisli H. HalldorssonNete Munk NielsenFrank GellerMads MelbyeDaniel F. GudbjartssonReynir T. GeirssonUnnur ThorsteinsdottirKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valgerdur Steinthorsdottir Gudmar Thorleifsson Kristrun Aradottir Bjarke Feenstra Asgeir Sigurdsson Lilja Stefansdottir Anna M. Kristinsdottir Florian Zink Gisli H. Halldorsson Nete Munk Nielsen Frank Geller Mads Melbye Daniel F. Gudbjartsson Reynir T. Geirsson Unnur Thorsteinsdottir Kari Stefansson Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
description	Endometriosis is a common gynaecological disease but the underlying pathogenesis is poorly understood, however there is a strong familial component. Here the authors conduct a genome wide association study and identify a novel susceptibility locus that correlates with disease severity.
format	article
author	Valgerdur Steinthorsdottir Gudmar Thorleifsson Kristrun Aradottir Bjarke Feenstra Asgeir Sigurdsson Lilja Stefansdottir Anna M. Kristinsdottir Florian Zink Gisli H. Halldorsson Nete Munk Nielsen Frank Geller Mads Melbye Daniel F. Gudbjartsson Reynir T. Geirsson Unnur Thorsteinsdottir Kari Stefansson
author_facet	Valgerdur Steinthorsdottir Gudmar Thorleifsson Kristrun Aradottir Bjarke Feenstra Asgeir Sigurdsson Lilja Stefansdottir Anna M. Kristinsdottir Florian Zink Gisli H. Halldorsson Nete Munk Nielsen Frank Geller Mads Melbye Daniel F. Gudbjartsson Reynir T. Geirsson Unnur Thorsteinsdottir Kari Stefansson
author_sort	Valgerdur Steinthorsdottir
title	Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
title_short	Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
title_full	Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
title_fullStr	Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
title_full_unstemmed	Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis
title_sort	common variants upstream of kdr encoding vegfr2 and in ttc39b associate with endometriosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6c41abb3afba4f8a8463de22de52ead8
work_keys_str_mv	AT valgerdursteinthorsdottir commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT gudmarthorleifsson commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT kristrunaradottir commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT bjarkefeenstra commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT asgeirsigurdsson commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT liljastefansdottir commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT annamkristinsdottir commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT florianzink commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT gislihhalldorsson commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT netemunknielsen commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT frankgeller commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT madsmelbye commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT danielfgudbjartsson commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT reynirtgeirsson commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT unnurthorsteinsdottir commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis AT karistefansson commonvariantsupstreamofkdrencodingvegfr2andinttc39bassociatewithendometriosis
_version_	1718382630168166400

Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis

Ejemplares similares