Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months

Rahul K Reddy,1 Maziar Lalezary,1 Stephen J Kim,1 Jeffrey A Kammer,1 Rachel W Kuchtey,1 Edward F Cherney,1 Franco M Recchia,2 Karen M Joos,1 Anita Agarwal,1 Janice C Law11Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Tennessee Retina, PC, Nashville, TN,...

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Autores principales:	Reddy RK, Lalezary M, Kim SJ, Kammer JA, Kuchtey RW, Cherney EF, Recchia FM, Joos KM, Agarwal A, Law JC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/6c427867471546b4b6346ddf8953bb1f
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spelling	oai:doaj.org-article:6c427867471546b4b6346ddf8953bb1f2021-12-02T03:17:14ZProspective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months1177-54671177-5483https://doaj.org/article/6c427867471546b4b6346ddf8953bb1f2013-09-01T00:00:00Zhttp://www.dovepress.com/prospective-retinal-and-optic-nerve-vitrectomy-evaluation-prove-study--a14234https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Rahul K Reddy,1 Maziar Lalezary,1 Stephen J Kim,1 Jeffrey A Kammer,1 Rachel W Kuchtey,1 Edward F Cherney,1 Franco M Recchia,2 Karen M Joos,1 Anita Agarwal,1 Janice C Law11Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Tennessee Retina, PC, Nashville, TN, USABackground: The purpose of this paper is to report the 3-month findings of the Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study.Methods: Eighty eyes of 40 participants undergoing vitrectomy were enrolled. Participants underwent baseline evaluation of the study (surgical) and fellow (control) eye that included: intraocular pressure, central corneal thickness, gonioscopy, cup-to-disc ratio measurement, color fundus and optic disc photography, automated perimetry, and optical coherence tomography of the macula and optic nerve. Evaluation was repeated at 3 months. Main outcome measures were changes in macula and retinal nerve fiber layer (RNFL) thickness and intraocular pressure.Results: All participants completed follow-up. Mean cup-to-disc ratio of study and fellow eyes at baseline was 0.43 ± 0.2 and 0.46 ± 0.2, respectively, and 13% of participants had undiagnosed narrow angles. There was no significant change in intraocular pressure, cup-to-disc ratio, or pattern standard deviation in study eyes compared with baseline or fellow eyes at 3 months. Vision improved in all study eyes at 3 months compared with baseline (P = 0.013), but remained significantly worse than fellow eyes (P < 0.001). Central subfield and temporal peripapillary RNFL thickness were significantly greater in eyes with epiretinal membrane (P < 0.05), and resolution after surgery correlated with visual improvement (P < 0.05).Conclusion: The 3-month results do not indicate any increased risk for open-angle glaucoma but suggest that a relatively high percentage of eyes may be at risk of angle closure glaucoma. Temporal RNFL thickness and central subfield were increased in eyes with epiretinal membrane, and resolution correlated with degree of visual recovery.Keywords: vitrectomy, open-angle glaucoma, intraocular pressure, epiretinal membrane, macular holeReddy RKLalezary MKim SJKammer JAKuchtey RWCherney EFRecchia FMJoos KMAgarwal ALaw JCDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1761-1769 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Reddy RK Lalezary M Kim SJ Kammer JA Kuchtey RW Cherney EF Recchia FM Joos KM Agarwal A Law JC Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months
description	Rahul K Reddy,1 Maziar Lalezary,1 Stephen J Kim,1 Jeffrey A Kammer,1 Rachel W Kuchtey,1 Edward F Cherney,1 Franco M Recchia,2 Karen M Joos,1 Anita Agarwal,1 Janice C Law11Department of Ophthalmology, Vanderbilt University School of Medicine, Nashville, TN, USA; 2Tennessee Retina, PC, Nashville, TN, USABackground: The purpose of this paper is to report the 3-month findings of the Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study.Methods: Eighty eyes of 40 participants undergoing vitrectomy were enrolled. Participants underwent baseline evaluation of the study (surgical) and fellow (control) eye that included: intraocular pressure, central corneal thickness, gonioscopy, cup-to-disc ratio measurement, color fundus and optic disc photography, automated perimetry, and optical coherence tomography of the macula and optic nerve. Evaluation was repeated at 3 months. Main outcome measures were changes in macula and retinal nerve fiber layer (RNFL) thickness and intraocular pressure.Results: All participants completed follow-up. Mean cup-to-disc ratio of study and fellow eyes at baseline was 0.43 ± 0.2 and 0.46 ± 0.2, respectively, and 13% of participants had undiagnosed narrow angles. There was no significant change in intraocular pressure, cup-to-disc ratio, or pattern standard deviation in study eyes compared with baseline or fellow eyes at 3 months. Vision improved in all study eyes at 3 months compared with baseline (P = 0.013), but remained significantly worse than fellow eyes (P < 0.001). Central subfield and temporal peripapillary RNFL thickness were significantly greater in eyes with epiretinal membrane (P < 0.05), and resolution after surgery correlated with visual improvement (P < 0.05).Conclusion: The 3-month results do not indicate any increased risk for open-angle glaucoma but suggest that a relatively high percentage of eyes may be at risk of angle closure glaucoma. Temporal RNFL thickness and central subfield were increased in eyes with epiretinal membrane, and resolution correlated with degree of visual recovery.Keywords: vitrectomy, open-angle glaucoma, intraocular pressure, epiretinal membrane, macular hole
format	article
author	Reddy RK Lalezary M Kim SJ Kammer JA Kuchtey RW Cherney EF Recchia FM Joos KM Agarwal A Law JC
author_facet	Reddy RK Lalezary M Kim SJ Kammer JA Kuchtey RW Cherney EF Recchia FM Joos KM Agarwal A Law JC
author_sort	Reddy RK
title	Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months
title_short	Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months
title_full	Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months
title_fullStr	Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months
title_full_unstemmed	Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months
title_sort	prospective retinal and optic nerve vitrectomy evaluation (prove) study: findings at 3 months
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/6c427867471546b4b6346ddf8953bb1f
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Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) study: findings at 3 months

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