Network analyses reveal pervasive functional regulation between proteases in the human protease web.

Proteolytic processing is an irreversible posttranslational modification affecting a large portion of the proteome. Protease-cleaved mediators frequently exhibit altered activity, and biological pathways are often regulated by proteolytic processing. Many of these mechanisms have not been appreciate...

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Autores principales: Nikolaus Fortelny, Jennifer H Cox, Reinhild Kappelhoff, Amanda E Starr, Philipp F Lange, Paul Pavlidis, Christopher M Overall
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/6c499b3dfca44b46afedb024015fd05d
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