COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS

The study aimed to compare the effectiveness of various pharmacotherapy regimens for infertility of tubo-peritoneal genesis. Under constant supervision were 96 patients referred to the hospital for diagnostic laparoscopy for infertility of tubo-peritoneal genesis, divided equally into 4 groups depen...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	O. B.J. Po, A. A. Konoplya, I. N. Medvedeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2021
Materias:	infertility of tubo-peritoneal genesis pharmacological correction of immunometabolic disorders Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/6c4a77d636ae47239619959c2d59a7f1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c4a77d636ae47239619959c2d59a7f1
record_format	dspace
spelling	oai:doaj.org-article:6c4a77d636ae47239619959c2d59a7f12021-11-18T08:03:51ZCOMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS1563-06252313-741X10.15789/1563-0625-CEO-1990https://doaj.org/article/6c4a77d636ae47239619959c2d59a7f12021-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1990https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe study aimed to compare the effectiveness of various pharmacotherapy regimens for infertility of tubo-peritoneal genesis. Under constant supervision were 96 patients referred to the hospital for diagnostic laparoscopy for infertility of tubo-peritoneal genesis, divided equally into 4 groups depending on the pharmacological treatment methods: the 1st group received basic pharmacotherapy (BPT) after endoscopic surgery (antibacterial, antifungal, vitamin therapy). Patients of groups 2-4, in addition to BPT, received Hepon, Cycloferon or Lavomax, respectively. The control group consisted of 38 gynecologically healthy women. Laboratory examination was performed within 24 hours after the operation and on the 30th day after BPT. Vaginocervical lavage and plasma were assayed for the activity of lipid peroxidation processes, the state of the antioxidant system, the level of stable nitric oxide metabolites, neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA, sIgA), components of the complement system (C3, C4, C5, C5А), phagocytic and oxygen-dependent activity of polymorphonuclear leukocytes. It was established that the use of immunomodulatory and antiviral activity medication with BPT according to the degree of increasing efficiency in the correction of immunometabolic laboratory parameters at the systemic and local level in infertility of tuboperitoneal genesis is as the following sequence: basic pharmacotherapy < basic pharmacotherapy + Hepon < basic pharmacotherapy + Cycloferon < basic pharmacotherapy + Lavomax.O. B.J. PoA. A. KonoplyaI. N. MedvedevaSPb RAACIarticleinfertility of tubo-peritoneal genesispharmacological correction of immunometabolic disordersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 23, Iss 4, Pp 927-932 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	infertility of tubo-peritoneal genesis pharmacological correction of immunometabolic disorders Immunologic diseases. Allergy RC581-607
spellingShingle	infertility of tubo-peritoneal genesis pharmacological correction of immunometabolic disorders Immunologic diseases. Allergy RC581-607 O. B.J. Po A. A. Konoplya I. N. Medvedeva COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS
description	The study aimed to compare the effectiveness of various pharmacotherapy regimens for infertility of tubo-peritoneal genesis. Under constant supervision were 96 patients referred to the hospital for diagnostic laparoscopy for infertility of tubo-peritoneal genesis, divided equally into 4 groups depending on the pharmacological treatment methods: the 1st group received basic pharmacotherapy (BPT) after endoscopic surgery (antibacterial, antifungal, vitamin therapy). Patients of groups 2-4, in addition to BPT, received Hepon, Cycloferon or Lavomax, respectively. The control group consisted of 38 gynecologically healthy women. Laboratory examination was performed within 24 hours after the operation and on the 30th day after BPT. Vaginocervical lavage and plasma were assayed for the activity of lipid peroxidation processes, the state of the antioxidant system, the level of stable nitric oxide metabolites, neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA, sIgA), components of the complement system (C3, C4, C5, C5А), phagocytic and oxygen-dependent activity of polymorphonuclear leukocytes. It was established that the use of immunomodulatory and antiviral activity medication with BPT according to the degree of increasing efficiency in the correction of immunometabolic laboratory parameters at the systemic and local level in infertility of tuboperitoneal genesis is as the following sequence: basic pharmacotherapy < basic pharmacotherapy + Hepon < basic pharmacotherapy + Cycloferon < basic pharmacotherapy + Lavomax.
format	article
author	O. B.J. Po A. A. Konoplya I. N. Medvedeva
author_facet	O. B.J. Po A. A. Konoplya I. N. Medvedeva
author_sort	O. B.J. Po
title	COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS
title_short	COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS
title_full	COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS
title_fullStr	COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS
title_full_unstemmed	COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS
title_sort	comparative effectiveness of various schemes of immunorehabilitation in infertility of tuboperitoneal genesis
publisher	SPb RAACI
publishDate	2021
url	https://doaj.org/article/6c4a77d636ae47239619959c2d59a7f1
work_keys_str_mv	AT objpo comparativeeffectivenessofvariousschemesofimmunorehabilitationininfertilityoftuboperitonealgenesis AT aakonoplya comparativeeffectivenessofvariousschemesofimmunorehabilitationininfertilityoftuboperitonealgenesis AT inmedvedeva comparativeeffectivenessofvariousschemesofimmunorehabilitationininfertilityoftuboperitonealgenesis
_version_	1718422291154468864

COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS

Ejemplares similares