The sedative effect of non-alcoholic beer in healthy female nurses.

<h4>Introduction</h4>The hop (Humulus lupulus L.), a component of beer, is a sedative plant whose pharmacological activity is principally due to its bitter resins, in particular to the α-acid degradation product 2-methyl-3-buten-2-ol. The mechanism of action of hop resin consists of rais...

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Autores principales:	Lourdes Franco, Cristina Sánchez, Rafael Bravo, Ana B Rodríguez, Carmen Barriga, Eulalia Romero, Javier Cubero
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6c4aafdedae14b0a93a8e165905ac8c6
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spelling	oai:doaj.org-article:6c4aafdedae14b0a93a8e165905ac8c62021-11-18T07:12:07ZThe sedative effect of non-alcoholic beer in healthy female nurses.1932-620310.1371/journal.pone.0037290https://doaj.org/article/6c4aafdedae14b0a93a8e165905ac8c62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22815680/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>The hop (Humulus lupulus L.), a component of beer, is a sedative plant whose pharmacological activity is principally due to its bitter resins, in particular to the α-acid degradation product 2-methyl-3-buten-2-ol. The mechanism of action of hop resin consists of raising the levels of the neurotransmitter γ-aminobutyric acid (GABA), an inhibitory neurotransmitter acting in the central nervous system (CNS).<h4>Objectives</h4>To analyze the sedative effect of hops as a component of non-alcoholic beer on the sleep/wake rhythm in a work-stressed population.<h4>Methods</h4>The experiment was conducted with healthy female nurses (n = 17) working rotating and/or night shifts. Overnight sleep and chronobiological parameters were assessed by actigraphy (Actiwatch®) after moderate ingestion of non-alcoholic beer containing hops (333 ml with 0.0% alcohol) with supper for 14 days (treatment). Data were obtained in comparison with her own control group without consumption of beer during supper.<h4>Results</h4>Actigraphy results demonstrated improvement of night sleep quality as regards the most important parameters: Sleep Latency diminished (p≤0.05) in the Treatment group (12.01±1.19 min) when compared to the Control group (20.50±4.21 min), as also did Total Activity (p≤0.05; Treatment group = 5284.78±836.99 activity pulses vs Control = 7258.78±898.89 activity pulses). In addition, anxiety as indexed by the State-Trait Anxiety Inventory (STAI) decreased in the Treatment group (State Anxiety 18.09±3.8 vs Control 20.69±2.14).<h4>Conclusion</h4>The moderate consumption of non-alcoholic beer will favour night-time rest, due in particular to its hop components, in addition to its other confirmed benefits for the organism.Lourdes FrancoCristina SánchezRafael BravoAna B RodríguezCarmen BarrigaEulalia RomeroJavier CuberoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e37290 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lourdes Franco Cristina Sánchez Rafael Bravo Ana B Rodríguez Carmen Barriga Eulalia Romero Javier Cubero The sedative effect of non-alcoholic beer in healthy female nurses.
description	<h4>Introduction</h4>The hop (Humulus lupulus L.), a component of beer, is a sedative plant whose pharmacological activity is principally due to its bitter resins, in particular to the α-acid degradation product 2-methyl-3-buten-2-ol. The mechanism of action of hop resin consists of raising the levels of the neurotransmitter γ-aminobutyric acid (GABA), an inhibitory neurotransmitter acting in the central nervous system (CNS).<h4>Objectives</h4>To analyze the sedative effect of hops as a component of non-alcoholic beer on the sleep/wake rhythm in a work-stressed population.<h4>Methods</h4>The experiment was conducted with healthy female nurses (n = 17) working rotating and/or night shifts. Overnight sleep and chronobiological parameters were assessed by actigraphy (Actiwatch®) after moderate ingestion of non-alcoholic beer containing hops (333 ml with 0.0% alcohol) with supper for 14 days (treatment). Data were obtained in comparison with her own control group without consumption of beer during supper.<h4>Results</h4>Actigraphy results demonstrated improvement of night sleep quality as regards the most important parameters: Sleep Latency diminished (p≤0.05) in the Treatment group (12.01±1.19 min) when compared to the Control group (20.50±4.21 min), as also did Total Activity (p≤0.05; Treatment group = 5284.78±836.99 activity pulses vs Control = 7258.78±898.89 activity pulses). In addition, anxiety as indexed by the State-Trait Anxiety Inventory (STAI) decreased in the Treatment group (State Anxiety 18.09±3.8 vs Control 20.69±2.14).<h4>Conclusion</h4>The moderate consumption of non-alcoholic beer will favour night-time rest, due in particular to its hop components, in addition to its other confirmed benefits for the organism.
format	article
author	Lourdes Franco Cristina Sánchez Rafael Bravo Ana B Rodríguez Carmen Barriga Eulalia Romero Javier Cubero
author_facet	Lourdes Franco Cristina Sánchez Rafael Bravo Ana B Rodríguez Carmen Barriga Eulalia Romero Javier Cubero
author_sort	Lourdes Franco
title	The sedative effect of non-alcoholic beer in healthy female nurses.
title_short	The sedative effect of non-alcoholic beer in healthy female nurses.
title_full	The sedative effect of non-alcoholic beer in healthy female nurses.
title_fullStr	The sedative effect of non-alcoholic beer in healthy female nurses.
title_full_unstemmed	The sedative effect of non-alcoholic beer in healthy female nurses.
title_sort	sedative effect of non-alcoholic beer in healthy female nurses.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6c4aafdedae14b0a93a8e165905ac8c6
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The sedative effect of non-alcoholic beer in healthy female nurses.

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