Undifferentiated laryngeal carcinoma with hyaline bodies in a cat

Abstract Background Primary laryngeal neoplasms are rare in cats, with lymphoma and squamous cell carcinoma being the most commonly diagnosed tumour types. These tumours are usually highly aggressive, difficult to treat, and have a poor prognosis. Here an undifferentiated laryngeal carcinoma with hy...

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Autores principales:	Filippo Torrigiani, Maria Elena Gelain, Laura Cavicchioli, Roberta Di Maggio, Tommaso Banzato, Federico Bonsembiante
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Carcinoma Cytology Immunohistochemistry Larynx Pancytokeratin Transmission electron microscopy Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/6c4ad68dde684eb985ac35251d94335f
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spelling	oai:doaj.org-article:6c4ad68dde684eb985ac35251d94335f2021-11-28T12:29:18ZUndifferentiated laryngeal carcinoma with hyaline bodies in a cat10.1186/s13028-021-00613-y1751-0147https://doaj.org/article/6c4ad68dde684eb985ac35251d94335f2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13028-021-00613-yhttps://doaj.org/toc/1751-0147Abstract Background Primary laryngeal neoplasms are rare in cats, with lymphoma and squamous cell carcinoma being the most commonly diagnosed tumour types. These tumours are usually highly aggressive, difficult to treat, and have a poor prognosis. Here an undifferentiated laryngeal carcinoma with hyaline bodies in a cat is reported. Case presentation A 13-year-old cat was presented for progressive respiratory signs. Diagnostic procedures revealed a partially obstructive laryngeal mass. Cytology was compatible with a poorly differentiated malignant tumour, with neoplastic cells frequently containing large intracytoplasmic hyaline bodies. After 1 month the patient was euthanised due to a worsening clinical condition and submitted for post-mortem examination, which confirmed the presence of two laryngeal masses. Histopathology confirmed the presence of an undifferentiated neoplasm with marked features of malignancy. Strong immunolabelling for pancytokeratin led to a diagnosis of undifferentiated carcinoma, however, histochemical and immunohistochemical investigations could not elucidate the origin of the large intracytoplasmic hyaline bodies observed in tumour cells, which appeared as non-membrane bound deposits of electron-dense material on transmission electron microscopy. Conclusion This is the first report of primary undifferentiated laryngeal carcinoma in a cat. Our case confirms the clinical features and the short survival that have been reported in other studies describing feline laryngeal tumours. Moreover, for the first time in feline literature, we describe the presence of intracytoplasmic hyaline bodies in neoplastic cells that were compatible with the so-called hyaline granules reported in different human cancers and also in the dog.Filippo TorrigianiMaria Elena GelainLaura CavicchioliRoberta Di MaggioTommaso BanzatoFederico BonsembianteBMCarticleCarcinomaCytologyImmunohistochemistryLarynxPancytokeratinTransmission electron microscopyVeterinary medicineSF600-1100ENActa Veterinaria Scandinavica, Vol 63, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Carcinoma Cytology Immunohistochemistry Larynx Pancytokeratin Transmission electron microscopy Veterinary medicine SF600-1100
spellingShingle	Carcinoma Cytology Immunohistochemistry Larynx Pancytokeratin Transmission electron microscopy Veterinary medicine SF600-1100 Filippo Torrigiani Maria Elena Gelain Laura Cavicchioli Roberta Di Maggio Tommaso Banzato Federico Bonsembiante Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
description	Abstract Background Primary laryngeal neoplasms are rare in cats, with lymphoma and squamous cell carcinoma being the most commonly diagnosed tumour types. These tumours are usually highly aggressive, difficult to treat, and have a poor prognosis. Here an undifferentiated laryngeal carcinoma with hyaline bodies in a cat is reported. Case presentation A 13-year-old cat was presented for progressive respiratory signs. Diagnostic procedures revealed a partially obstructive laryngeal mass. Cytology was compatible with a poorly differentiated malignant tumour, with neoplastic cells frequently containing large intracytoplasmic hyaline bodies. After 1 month the patient was euthanised due to a worsening clinical condition and submitted for post-mortem examination, which confirmed the presence of two laryngeal masses. Histopathology confirmed the presence of an undifferentiated neoplasm with marked features of malignancy. Strong immunolabelling for pancytokeratin led to a diagnosis of undifferentiated carcinoma, however, histochemical and immunohistochemical investigations could not elucidate the origin of the large intracytoplasmic hyaline bodies observed in tumour cells, which appeared as non-membrane bound deposits of electron-dense material on transmission electron microscopy. Conclusion This is the first report of primary undifferentiated laryngeal carcinoma in a cat. Our case confirms the clinical features and the short survival that have been reported in other studies describing feline laryngeal tumours. Moreover, for the first time in feline literature, we describe the presence of intracytoplasmic hyaline bodies in neoplastic cells that were compatible with the so-called hyaline granules reported in different human cancers and also in the dog.
format	article
author	Filippo Torrigiani Maria Elena Gelain Laura Cavicchioli Roberta Di Maggio Tommaso Banzato Federico Bonsembiante
author_facet	Filippo Torrigiani Maria Elena Gelain Laura Cavicchioli Roberta Di Maggio Tommaso Banzato Federico Bonsembiante
author_sort	Filippo Torrigiani
title	Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
title_short	Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
title_full	Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
title_fullStr	Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
title_full_unstemmed	Undifferentiated laryngeal carcinoma with hyaline bodies in a cat
title_sort	undifferentiated laryngeal carcinoma with hyaline bodies in a cat
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6c4ad68dde684eb985ac35251d94335f
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Undifferentiated laryngeal carcinoma with hyaline bodies in a cat

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