ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery and ribosomes required for efficient ribosome rele...

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Autores principales:	Lucas D. Serdar, DaJuan L. Whiteside, Kristian E. Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c4b427687ad4141ab4421be6022f015
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spelling	oai:doaj.org-article:6c4b427687ad4141ab4421be6022f0152021-12-02T16:50:15ZATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons10.1038/ncomms140212041-1723https://doaj.org/article/6c4b427687ad4141ab4421be6022f0152016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms14021https://doaj.org/toc/2041-1723Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery and ribosomes required for efficient ribosome release at premature termination codons.Lucas D. SerdarDaJuan L. WhitesideKristian E. BakerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lucas D. Serdar DaJuan L. Whiteside Kristian E. Baker ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
description	Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery and ribosomes required for efficient ribosome release at premature termination codons.
format	article
author	Lucas D. Serdar DaJuan L. Whiteside Kristian E. Baker
author_facet	Lucas D. Serdar DaJuan L. Whiteside Kristian E. Baker
author_sort	Lucas D. Serdar
title	ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
title_short	ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
title_full	ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
title_fullStr	ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
title_full_unstemmed	ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons
title_sort	atp hydrolysis by upf1 is required for efficient translation termination at premature stop codons
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6c4b427687ad4141ab4421be6022f015
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ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

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