ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons

Nonsense-mediated mRNA decay (NMD) is a quality control pathway that recognizes and degrades transcripts harbouring nonsense mutations. Here the authors show that the ATPase activity of UPF1 mediates functional interactions between the NMD machinery and ribosomes required for efficient ribosome rele...

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Autores principales: Lucas D. Serdar, DaJuan L. Whiteside, Kristian E. Baker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/6c4b427687ad4141ab4421be6022f015
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