Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies

A straightforward method for synthesizing at the multigram scale a low molecular weight PCTA-based gadolinium complex bearing an ionizable oxyacetic chain on the pyridine unit was described, together with its encapsulation within a nanohydrogel matrix. The ionic gelation occurred between chitosan an...

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Autores principales:	Fabienne Dioury, Maité Callewaert, Cyril Cadiou, Céline Henoumont, Michael Molinari, Sophie Laurent, Christophe Portefaix, Marc Port, Francoise Chuburu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	PCTA chelating agent Gadolinium contrast agent Nanohydrogel Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/6c4c5efee7f24c0388493c111a7fc19f
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spelling	oai:doaj.org-article:6c4c5efee7f24c0388493c111a7fc19f2021-11-12T04:32:27ZPyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies2211-715610.1016/j.rechem.2021.100237https://doaj.org/article/6c4c5efee7f24c0388493c111a7fc19f2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2211715621001429https://doaj.org/toc/2211-7156A straightforward method for synthesizing at the multigram scale a low molecular weight PCTA-based gadolinium complex bearing an ionizable oxyacetic chain on the pyridine unit was described, together with its encapsulation within a nanohydrogel matrix. The ionic gelation occurred between chitosan and hyaluronic acid, reinforced by crosslinking with sodium tripolyphosphate. The resulting nanogels are spherical and narrowly monodisperse. They are stable for at least four months at room temperature in water and in media of higher ionic strength (NaCl 0.9%, PBS). They display an enhanced longitudinal relaxivity r1 of 15.9 and 12.1 mM−1.s−1 at 20 MHz and 60 MHz at 37 °C respectively which is at least 4 times higher than that of DOTAREM®.Fabienne DiouryMaité CallewaertCyril CadiouCéline HenoumontMichael MolinariSophie LaurentChristophe PortefaixMarc PortFrancoise ChuburuElsevierarticlePCTA chelating agentGadolinium contrast agentNanohydrogelChemistryQD1-999ENResults in Chemistry, Vol 3, Iss , Pp 100237- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	PCTA chelating agent Gadolinium contrast agent Nanohydrogel Chemistry QD1-999
spellingShingle	PCTA chelating agent Gadolinium contrast agent Nanohydrogel Chemistry QD1-999 Fabienne Dioury Maité Callewaert Cyril Cadiou Céline Henoumont Michael Molinari Sophie Laurent Christophe Portefaix Marc Port Francoise Chuburu Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
description	A straightforward method for synthesizing at the multigram scale a low molecular weight PCTA-based gadolinium complex bearing an ionizable oxyacetic chain on the pyridine unit was described, together with its encapsulation within a nanohydrogel matrix. The ionic gelation occurred between chitosan and hyaluronic acid, reinforced by crosslinking with sodium tripolyphosphate. The resulting nanogels are spherical and narrowly monodisperse. They are stable for at least four months at room temperature in water and in media of higher ionic strength (NaCl 0.9%, PBS). They display an enhanced longitudinal relaxivity r1 of 15.9 and 12.1 mM−1.s−1 at 20 MHz and 60 MHz at 37 °C respectively which is at least 4 times higher than that of DOTAREM®.
format	article
author	Fabienne Dioury Maité Callewaert Cyril Cadiou Céline Henoumont Michael Molinari Sophie Laurent Christophe Portefaix Marc Port Francoise Chuburu
author_facet	Fabienne Dioury Maité Callewaert Cyril Cadiou Céline Henoumont Michael Molinari Sophie Laurent Christophe Portefaix Marc Port Francoise Chuburu
author_sort	Fabienne Dioury
title	Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
title_short	Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
title_full	Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
title_fullStr	Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
title_full_unstemmed	Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies
title_sort	pyclen-based gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive mri nanoprobes: synthesis and relaxation studies
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/6c4c5efee7f24c0388493c111a7fc19f
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Pyclen-based Gd complex with ionisable side-chain as a contrastophore for the design of hypersensitive MRI nanoprobes: Synthesis and relaxation studies

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