DNA end resection requires constitutive sumoylation of CtIP by CBX4

The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.

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Auteurs principaux:	Isabel Soria-Bretones, Cristina Cepeda-García, Cintia Checa-Rodriguez, Vincent Heyer, Bernardo Reina-San-Martin, Evi Soutoglou, Pablo Huertas
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/6c4d8e6d5aac493ba82944e261ae1bdc
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spelling	oai:doaj.org-article:6c4d8e6d5aac493ba82944e261ae1bdc2021-12-02T13:24:05ZDNA end resection requires constitutive sumoylation of CtIP by CBX410.1038/s41467-017-00183-62041-1723https://doaj.org/article/6c4d8e6d5aac493ba82944e261ae1bdc2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00183-6https://doaj.org/toc/2041-1723The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.Isabel Soria-BretonesCristina Cepeda-GarcíaCintia Checa-RodriguezVincent HeyerBernardo Reina-San-MartinEvi SoutoglouPablo HuertasNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Isabel Soria-Bretones Cristina Cepeda-García Cintia Checa-Rodriguez Vincent Heyer Bernardo Reina-San-Martin Evi Soutoglou Pablo Huertas DNA end resection requires constitutive sumoylation of CtIP by CBX4
description	The choice between non-homologous end-joining and homologous recombination to repair a DNA double-strand break depends on activation of the end resection machinery. Here the authors show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.
format	article
author	Isabel Soria-Bretones Cristina Cepeda-García Cintia Checa-Rodriguez Vincent Heyer Bernardo Reina-San-Martin Evi Soutoglou Pablo Huertas
author_facet	Isabel Soria-Bretones Cristina Cepeda-García Cintia Checa-Rodriguez Vincent Heyer Bernardo Reina-San-Martin Evi Soutoglou Pablo Huertas
author_sort	Isabel Soria-Bretones
title	DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_short	DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_full	DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_fullStr	DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_full_unstemmed	DNA end resection requires constitutive sumoylation of CtIP by CBX4
title_sort	dna end resection requires constitutive sumoylation of ctip by cbx4
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/6c4d8e6d5aac493ba82944e261ae1bdc
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DNA end resection requires constitutive sumoylation of CtIP by CBX4

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