Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation

Mechanisms regulating the formation of pre-metastatic niches remain poorly understood. Here, the authors show that ITGBL1-containing extracellular vesicles derived from primary colorectal cancer cells activate the production of inflammatory cytokines by resident fibroblasts in distant organs, promot...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qing Ji, Lihong Zhou, Hua Sui, Liu Yang, Xinnan Wu, Qing Song, Ru Jia, Ruixiao Li, Jian Sun, Ziyuan Wang, Ningning Liu, Yuanyuan Feng, Xiaoting Sun, Gang Cai, Yu Feng, Jianfeng Cai, Yihai Cao, Guoxiang Cai, Yan Wang, Qi Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c5236b721274f3a8bd1e08b42a1fdf5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6c5236b721274f3a8bd1e08b42a1fdf5
record_format	dspace
spelling	oai:doaj.org-article:6c5236b721274f3a8bd1e08b42a1fdf52021-12-02T16:49:15ZPrimary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation10.1038/s41467-020-14869-x2041-1723https://doaj.org/article/6c5236b721274f3a8bd1e08b42a1fdf52020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14869-xhttps://doaj.org/toc/2041-1723Mechanisms regulating the formation of pre-metastatic niches remain poorly understood. Here, the authors show that ITGBL1-containing extracellular vesicles derived from primary colorectal cancer cells activate the production of inflammatory cytokines by resident fibroblasts in distant organs, promoting metastatic cancer growth.Qing JiLihong ZhouHua SuiLiu YangXinnan WuQing SongRu JiaRuixiao LiJian SunZiyuan WangNingning LiuYuanyuan FengXiaoting SunGang CaiYu FengJianfeng CaiYihai CaoGuoxiang CaiYan WangQi LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing Ji Lihong Zhou Hua Sui Liu Yang Xinnan Wu Qing Song Ru Jia Ruixiao Li Jian Sun Ziyuan Wang Ningning Liu Yuanyuan Feng Xiaoting Sun Gang Cai Yu Feng Jianfeng Cai Yihai Cao Guoxiang Cai Yan Wang Qi Li Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
description	Mechanisms regulating the formation of pre-metastatic niches remain poorly understood. Here, the authors show that ITGBL1-containing extracellular vesicles derived from primary colorectal cancer cells activate the production of inflammatory cytokines by resident fibroblasts in distant organs, promoting metastatic cancer growth.
format	article
author	Qing Ji Lihong Zhou Hua Sui Liu Yang Xinnan Wu Qing Song Ru Jia Ruixiao Li Jian Sun Ziyuan Wang Ningning Liu Yuanyuan Feng Xiaoting Sun Gang Cai Yu Feng Jianfeng Cai Yihai Cao Guoxiang Cai Yan Wang Qi Li
author_facet	Qing Ji Lihong Zhou Hua Sui Liu Yang Xinnan Wu Qing Song Ru Jia Ruixiao Li Jian Sun Ziyuan Wang Ningning Liu Yuanyuan Feng Xiaoting Sun Gang Cai Yu Feng Jianfeng Cai Yihai Cao Guoxiang Cai Yan Wang Qi Li
author_sort	Qing Ji
title	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
title_short	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
title_full	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
title_fullStr	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
title_full_unstemmed	Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
title_sort	primary tumors release itgbl1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c5236b721274f3a8bd1e08b42a1fdf5
work_keys_str_mv	AT qingji primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT lihongzhou primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT huasui primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT liuyang primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT xinnanwu primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT qingsong primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT rujia primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT ruixiaoli primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT jiansun primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT ziyuanwang primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT ningningliu primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT yuanyuanfeng primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT xiaotingsun primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT gangcai primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT yufeng primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT jianfengcai primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT yihaicao primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT guoxiangcai primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT yanwang primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation AT qili primarytumorsreleaseitgbl1richextracellularvesiclestopromotedistalmetastatictumorgrowththroughfibroblastnicheformation
_version_	1718383401189244928

Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation

Ejemplares similares