Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth

The role of neurons and T cells in glioma progression remains poorly understood. Here the authors show that midkine-dependent activation of a neuron-T cell-microglia axis promotes the growth of optic pathway gliomas.

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Autores principales:	Xiaofan Guo, Yuan Pan, Min Xiong, Shilpa Sanapala, Corina Anastasaki, Olivia Cobb, Sonika Dahiya, David H. Gutmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6c5c63d7270c439b8c0919d2b7cf92d2
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id	oai:doaj.org-article:6c5c63d7270c439b8c0919d2b7cf92d2
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spelling	oai:doaj.org-article:6c5c63d7270c439b8c0919d2b7cf92d22021-12-02T15:39:17ZMidkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth10.1038/s41467-020-15770-32041-1723https://doaj.org/article/6c5c63d7270c439b8c0919d2b7cf92d22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15770-3https://doaj.org/toc/2041-1723The role of neurons and T cells in glioma progression remains poorly understood. Here the authors show that midkine-dependent activation of a neuron-T cell-microglia axis promotes the growth of optic pathway gliomas.Xiaofan GuoYuan PanMin XiongShilpa SanapalaCorina AnastasakiOlivia CobbSonika DahiyaDavid H. GutmannNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaofan Guo Yuan Pan Min Xiong Shilpa Sanapala Corina Anastasaki Olivia Cobb Sonika Dahiya David H. Gutmann Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
description	The role of neurons and T cells in glioma progression remains poorly understood. Here the authors show that midkine-dependent activation of a neuron-T cell-microglia axis promotes the growth of optic pathway gliomas.
format	article
author	Xiaofan Guo Yuan Pan Min Xiong Shilpa Sanapala Corina Anastasaki Olivia Cobb Sonika Dahiya David H. Gutmann
author_facet	Xiaofan Guo Yuan Pan Min Xiong Shilpa Sanapala Corina Anastasaki Olivia Cobb Sonika Dahiya David H. Gutmann
author_sort	Xiaofan Guo
title	Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
title_short	Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
title_full	Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
title_fullStr	Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
title_full_unstemmed	Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
title_sort	midkine activation of cd8+ t cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6c5c63d7270c439b8c0919d2b7cf92d2
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Midkine activation of CD8+ T cells establishes a neuron–immune–cancer axis responsible for low-grade glioma growth

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