A one-degree-of-freedom test for supra-multiplicativity of SNP effects.

A one-degree-of-freedom test for supra-multiplicativity of SNP effects.

Deviation from multiplicativity of genetic risk factors is biologically plausible and might explain why Genome-wide association studies (GWAS) so far could unravel only a portion of disease heritability. Still, evidence for SNP-SNP epistasis has rarely been reported, suggesting that 2-SNP models are...

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Autores principales: Christine Herold, Alfredo Ramirez, Dmitriy Drichel, André Lacour, Tatsiana Vaitsiakhovich, Markus M Nöthen, Frank Jessen, Wolfgang Maier, Tim Becker
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/6c5cb3d93e614073a9409faf05527265
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