The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) sub...
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2021
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oai:doaj.org-article:6c5e32a32732410d960ea32d7edadb8b2021-12-02T20:09:21ZThe methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.1932-620310.1371/journal.pone.0254267https://doaj.org/article/6c5e32a32732410d960ea32d7edadb8b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254267https://doaj.org/toc/1932-6203Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) subtypes is not fully understood. In this study, the MTHFR C677T polymorphism was genotyped in 490 individuals with or without BC from southwestern China. Analysis of the association between the MTHFR C677T polymorphism and BC revealed that there was a significant association between the MTHFR C677T polymorphism and triple-negative breast cancer (TNBC) (OR = 2.83, 95% CI: 1.12-9.51, P = 0.0401). Furthermore, the MTHFR C677T polymorphism can also serve as a protective factor in luminal A breast cancer (OR = 0.57, 95% CI: 0.34-0.94, P = 0.0258). Evaluation of the association between the MTHFR C677T polymorphism and clinical characteristics indicated that people who suffered from hypertension had an increased risk for BC (OR = 2.27; 95% CI: 1.08-4.6; P = 0.0264), especially TNBC (OR = 215.38; 95% CI: 2.45-84430.3; P = 0.0317). Our results suggest that the MTHFR C677T polymorphism is significantly associated with susceptibility to luminal B breast cancer and TNBC.Zhen LiJi ZhangWei ZouQi XuSiyuan LiJie WuLi ZhuYunjiao ZhangLei XuYing ZhangQingsong LuoJianyun NieXingxu LiTianning ZouCeshi ChenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254267 (2021) |
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Medicine R Science Q Zhen Li Ji Zhang Wei Zou Qi Xu Siyuan Li Jie Wu Li Zhu Yunjiao Zhang Lei Xu Ying Zhang Qingsong Luo Jianyun Nie Xingxu Li Tianning Zou Ceshi Chen The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China. |
| description |
Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. The MTHFR C677T polymorphism influences many biological processes, including tumorigenesis. However, the association between the MTHFR C677T polymorphism and breast cancer (BC) subtypes is not fully understood. In this study, the MTHFR C677T polymorphism was genotyped in 490 individuals with or without BC from southwestern China. Analysis of the association between the MTHFR C677T polymorphism and BC revealed that there was a significant association between the MTHFR C677T polymorphism and triple-negative breast cancer (TNBC) (OR = 2.83, 95% CI: 1.12-9.51, P = 0.0401). Furthermore, the MTHFR C677T polymorphism can also serve as a protective factor in luminal A breast cancer (OR = 0.57, 95% CI: 0.34-0.94, P = 0.0258). Evaluation of the association between the MTHFR C677T polymorphism and clinical characteristics indicated that people who suffered from hypertension had an increased risk for BC (OR = 2.27; 95% CI: 1.08-4.6; P = 0.0264), especially TNBC (OR = 215.38; 95% CI: 2.45-84430.3; P = 0.0317). Our results suggest that the MTHFR C677T polymorphism is significantly associated with susceptibility to luminal B breast cancer and TNBC. |
| format |
article |
| author |
Zhen Li Ji Zhang Wei Zou Qi Xu Siyuan Li Jie Wu Li Zhu Yunjiao Zhang Lei Xu Ying Zhang Qingsong Luo Jianyun Nie Xingxu Li Tianning Zou Ceshi Chen |
| author_facet |
Zhen Li Ji Zhang Wei Zou Qi Xu Siyuan Li Jie Wu Li Zhu Yunjiao Zhang Lei Xu Ying Zhang Qingsong Luo Jianyun Nie Xingxu Li Tianning Zou Ceshi Chen |
| author_sort |
Zhen Li |
| title |
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China. |
| title_short |
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China. |
| title_full |
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China. |
| title_fullStr |
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China. |
| title_full_unstemmed |
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China. |
| title_sort |
methylenetetrahydrofolate reductase (mthfr) c677t gene polymorphism is associated with breast cancer subtype susceptibility in southwestern china. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/6c5e32a32732410d960ea32d7edadb8b |
| work_keys_str_mv |
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