Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways

Yinghua Li,* Zhengfang Lin,* Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu Center Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China *These authors contributed equally to this work Introduction: As a therapeuti...

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Autores principales:	Li Y, Lin Z, Guo M, Zhao M, Xia Y, Wang C, Xu T, Zhu B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Selenium nanoparticles Amantadine Influenza virus Apoptosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6c60bda584094bb5885a5e409d69e074
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spelling	oai:doaj.org-article:6c60bda584094bb5885a5e409d69e0742021-12-02T04:47:11ZInhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways1178-2013https://doaj.org/article/6c60bda584094bb5885a5e409d69e0742018-04-01T00:00:00Zhttps://www.dovepress.com/inhibition-of-h1n1-influenza-virus-induced-apoptosis-by-functionalized-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yinghua Li,* Zhengfang Lin,* Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu Center Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China *These authors contributed equally to this work Introduction: As a therapeutic antiviral agent, the clinical application of amantadine (AM) is limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses and meet the growing demand of clinical diagnosis, the use of biological nanoparticles (NPs) has increased in order to develop novel anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity and excellent activities has attracted increasing attention for biomedical intervention in recent years.Methods and results: In the present study, surface decoration of selenium NPs by AM (Se@AM) was designed to reverse drug resistance caused by influenza virus infection. Se@AM with less toxicity remarkably inhibited the ability of H1N1 influenza to infect host cells through suppression of the neuraminidase activity. Moreover, Se@AM could prevent H1N1 from infecting Madin Darby Canine Kidney cell line and causing cell apoptosis supported by DNA fragmentation and chromatin condensation. Furthermore, Se@AM obviously inhibited the generation of reactive oxygen species and activation of phosphorylation of AKT.Conclusion: These results demonstrate that Se@AM is a potentially efficient antiviral pharmaceutical agent for H1N1 influenza virus. Keywords: selenium nanoparticles, amantadine, influenza virus, apoptosis, nanodrugLi YLin ZGuo MZhao MXia YWang CXu TZhu BDove Medical PressarticleSelenium nanoparticlesAmantadineInfluenza virusApoptosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2005-2016 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Selenium nanoparticles Amantadine Influenza virus Apoptosis Medicine (General) R5-920
spellingShingle	Selenium nanoparticles Amantadine Influenza virus Apoptosis Medicine (General) R5-920 Li Y Lin Z Guo M Zhao M Xia Y Wang C Xu T Zhu B Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways
description	Yinghua Li,* Zhengfang Lin,* Min Guo, Mingqi Zhao, Yu Xia, Changbing Wang, Tiantian Xu, Bing Zhu Center Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China *These authors contributed equally to this work Introduction: As a therapeutic antiviral agent, the clinical application of amantadine (AM) is limited by the emergence of drug-resistant viruses. To overcome the drug-resistant viruses and meet the growing demand of clinical diagnosis, the use of biological nanoparticles (NPs) has increased in order to develop novel anti-influenza drugs. The antiviral activity of selenium NPs with low toxicity and excellent activities has attracted increasing attention for biomedical intervention in recent years.Methods and results: In the present study, surface decoration of selenium NPs by AM (Se@AM) was designed to reverse drug resistance caused by influenza virus infection. Se@AM with less toxicity remarkably inhibited the ability of H1N1 influenza to infect host cells through suppression of the neuraminidase activity. Moreover, Se@AM could prevent H1N1 from infecting Madin Darby Canine Kidney cell line and causing cell apoptosis supported by DNA fragmentation and chromatin condensation. Furthermore, Se@AM obviously inhibited the generation of reactive oxygen species and activation of phosphorylation of AKT.Conclusion: These results demonstrate that Se@AM is a potentially efficient antiviral pharmaceutical agent for H1N1 influenza virus. Keywords: selenium nanoparticles, amantadine, influenza virus, apoptosis, nanodrug
format	article
author	Li Y Lin Z Guo M Zhao M Xia Y Wang C Xu T Zhu B
author_facet	Li Y Lin Z Guo M Zhao M Xia Y Wang C Xu T Zhu B
author_sort	Li Y
title	Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways
title_short	Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways
title_full	Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways
title_fullStr	Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways
title_full_unstemmed	Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways
title_sort	inhibition of h1n1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ros-mediated akt signaling pathways
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/6c60bda584094bb5885a5e409d69e074
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Inhibition of H1N1 influenza virus-induced apoptosis by functionalized selenium nanoparticles with amantadine through ROS-mediated AKT signaling pathways

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